Magnetic resonance and ionizing radiation: a comparative evaluation in vitro of oncogenic and genotoxic potential

Journal Article · Sun Jul 01 00:00:00 EDT 1984 · Radiology; (United States)

DOI:https://doi.org/10.1148/radiology.152.1.6729111· OSTI ID:6981205

Geard, C R; Osmak, R S; Hall, E J; Simon, H E; Maudsley, A A; Hilal, S K

This paper describes experiments designed to investigate possible biological hazards associated with magnetic resonance (MR) imaging. Mouse C3H 10T1/2 cells were exposed to a powerful magnetic field for periods up to 17 hours together with pulsed field gradients and radio-frequency excitation and compared with untreated controls and cells exposed to gamma rays. In the case of oncogenic transformation, no significant difference could be demonstrated between controls and either the gamma-irradiated or MR-exposed cells. When mitotic cells were examined for chromosomal alterations, the frequencies of both chromosomal aberrations per cell and sister chromatid exchanges per chromosome were signifcantly enhanced over control levels after ionizing radiation exposures but were similar to control (or less) after MR exposures. These studies confirm the known deleterious effects of ionizing radiation (even at low doses) for chromosomal damage, if not for oncogenic transformation, yet show that MR exposures even of long duration at high field strengths do not result in effects greater than 0.3 Gy of gamma rays.

• Research Organization: Columbia Univ., New York, NY
• DOE Contract Number: AC02-83ER60142
• OSTI ID: 6981205
• Journal Information: Radiology; (United States), Vol. 152:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CHROMOSOMAL ABERRATIONS
RADIOINDUCTION
FIBROBLASTS
BIOLOGICAL RADIATION EFFECTS
GAMMA RADIATION
COMPARATIVE EVALUATIONS
NUCLEAR MAGNETIC RESONANCE
ONCOGENIC TRANSFORMATIONS
EXPERIMENTAL DATA
IN VITRO
MICE
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
CONNECTIVE TISSUE CELLS
DATA
ELECTROMAGNETIC RADIATION
INFORMATION
IONIZING RADIATIONS
MAGNETIC RESONANCE
MAMMALS
MUTATIONS
NUMERICAL DATA
RADIATION EFFECTS
RADIATIONS
RESONANCE
RODENTS
SOMATIC CELLS
VERTEBRATES
560121* - Radiation Effects on Cells- External Source- (-1987)