Method and apparatus for fringe-scanning chromosome analysis

Patent · 31 August 1983

OSTI ID:6966114

Norgren, R M; Gray, J W; Hirschfeld, T B

Apparatus and method are provided for analyzing sub-micron-sized features of microscopic particles. Two central features of the invention are (1) constraining microscopic particles to flow with substantially constant orientation through a predetermined interference fringe pattern, and (2) estimating particle structure by analyzing its fringe profile. The invention allows nearly an order of magnitude higher resolution of chromosome structure than possible with currently available flow system techniques. The invention allows rapid and accurate flow karyotyping of chromosomes.

• DOE Contract Number: W-7405-ENG-48
• Assignee: Dept. of Energy
• Patent Number(s): None
• Application Number: ON: DE84010873
• OSTI ID: 6966114
• Country of Publication: United States
• Language: English

Related Subjects

550300* -- Cytology
59 BASIC BIOLOGICAL SCIENCES
ALGORITHMS
CELL FLOW SYSTEMS
CHROMOSOMES
DESIGN
FOURIER TRANSFORMATION
INTEGRAL TRANSFORMATIONS
INTERFEROMETRY
KARYOTYPE
LASERS
MATHEMATICAL LOGIC
TRANSFORMATIONS