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Title: Karlson ozone sterilizer. Final report

Abstract

The authors have a functional sterilization system employing ozone as a sterilization agent. This final report covers the work that led to the first medical sterilizer using ozone as the sterilizing agent. The specifications and the final design were set by hospital operating room personnel and public safety standards. Work on kill tests using bacteria, viruses and fungi determined the necessary time and concentration of ozone necessary for sterilization. These data were used in the Karlson Ozone Sterilizer to determine the length of the steps of the operating cycle and the concentration of ozone to be used. 27 references.

Authors:
Publication Date:
Research Org.:
Life Support Systems, Erie, PA (USA)
OSTI Identifier:
6965550
Report Number(s):
DOE/CE/25082-T1
ON: TI84011489
DOE Contract Number:
FG01-82CE25082
Resource Type:
Technical Report
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 59 BASIC BIOLOGICAL SCIENCES; MEDICAL SUPPLIES; STERILIZATION; OZONE; BIOLOGICAL EFFECTS; ASPERGILLUS; BACILLUS; CANDIDA; MYCOBACTERIUM; PENICILLIUM; PROTEUS; STAPHYLOCOCCUS; STREPTOCOCCUS; SURGICAL MATERIALS; VIRUSES; BACTERIA; FUNGI; MATERIALS; MICROORGANISMS; PARASITES; PLANTS; YEASTS; 550600* - Medicine; 550700 - Microbiology

Citation Formats

Karlson, E. Karlson ozone sterilizer. Final report. United States: N. p., 1984. Web.
Karlson, E. Karlson ozone sterilizer. Final report. United States.
Karlson, E. 1984. "Karlson ozone sterilizer. Final report". United States. doi:.
@article{osti_6965550,
title = {Karlson ozone sterilizer. Final report},
author = {Karlson, E.},
abstractNote = {The authors have a functional sterilization system employing ozone as a sterilization agent. This final report covers the work that led to the first medical sterilizer using ozone as the sterilizing agent. The specifications and the final design were set by hospital operating room personnel and public safety standards. Work on kill tests using bacteria, viruses and fungi determined the necessary time and concentration of ozone necessary for sterilization. These data were used in the Karlson Ozone Sterilizer to determine the length of the steps of the operating cycle and the concentration of ozone to be used. 27 references.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = 1984,
month = 5
}

Technical Report:
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  • A hazard and operability (HAZOP) study was conducted on a sterilizer supplied by compressed gas cylinders of ethylene-oxide (EtO). The sterilizer installation, equipment, and operational procedures were reviewed, and recommendations were developed both specifically for the studied installation and for the generic installation. The sterilizer consisted of a jacketed chamber and associated pumps, pipes, filters, valves and other equipment. Sterilizer facility design, sterilizer equipment design, leak monitoring, system utilities, equipment maintenance, and operational procedures were discussed. These recommendations should provide guidance to hospitals installing EtO sterilizers. The study also showed how the HAZOP study procedures which are typically used inmore » large chemical facilities can be used on a small scale setting. The HAZOP study involved evaluating the facility as a series of systems. Log sheets of information gathered were included in the report. A process diagram of an EtO sterilizer was included along with a schematic of EtO piping from tanks to sterilizer, a schematic of EtO sample line, calibration gas line, and carrier gas line, and schematics of the air inlet line to chamber and the piping from EtO tank to supply valve.« less
  • A walk-through survey was conducted at American Sterilizer Company, Erie, Pennsylvania in May, 1984. The purpose of the study was to determine the feasibility of including the facility in a NIOSH industrywide mortality/industrial hygiene study of ethylene-oxide exposure. The company produced sterilizers for hospitals and used ethylene-oxide to test the sterilizers for air leaks and gauge function from 1956 to 1982. The authors conclude that the facility meets most eligibility requirements for the NIOSH survey: having at least 400 person years of exposure, adequate personnel records, and no serious confounding exposure, to a known leukemogen. The facility should be tentativelymore » included in the NIOSH study.« less
  • The report gives results of a study of a commonly used commercially available ozone generator, undertaken to determine its impact on indoor ozone levels. Experiments were conducted in a typical mechanically ventilated office and in a test house. The generated ozone and the in-room ozone concentrations were measured. The results showed that, when the unit was operated at the manufacturer's recommended setting, it generated little if any ozone. The indoor concentrations in the case were not significantly above natural background. When operated at the maximum setting, the generator produced large amounts of ozone: over 100 ppb in well ventilated spaces,more » and nearly 1 ppm in poorly ventilated spaces. When the ozone generator was turned off, ozone levels quickly returned to background. No measurements were made to determine the effect of the device on other aspects of indoor air quality, such as the elimination of volatile organic compounds.« less
  • The project was designed to assess the contribution of transported pollutants to violations of the state ozone standard within the air basins covered by the report using existing data and advanced data analysis techniques. The objectives of the project were to determine the characteristics of ozone and ozone precursor transport within the California air basins covered by the report and to identify whether the contribution of transported pollutants to ozone violations in each downwind area was inconsequential, significant, or overwhelming, relative to locally-emitted pollutants. The precursor pollutants of interest were nitrogen oxides and reactive organic gases. The project evaluated transportmore » to the following areas: The Broader Sacramento Area and the Upper Sacramento Valley; The North Central Coast Air Basin; The Southeast Desert Air Basin (SEDAB); and the Imperial County portion of the SEDAB.« less
  • An updated version of the Ozone Isopleth Plotting Program was developed for use with EKMA to calculate emission reductions needed to achieve the air-quality standard for ozone. The program, called OZIPM-IV (Ozone Isopleth Plotting with Optional Mechanisms - Version IV), contains the new Carbon-Bond Mechanism-IV (CBM-IV). In addition to containing a new mechanism, the OZIPM-IV expands on earlier versions of the code by providing a wider compatibility between computers, an improved isopleth plotting package, expanded user interaction with control-strategy calculations and a new option for determining credits for reductions in carbon monoxide emissions. Volume 1 of the report serves asmore » the User's Manual for OZIPM-IV. Volume 2 contains the listing of the FORTRAN computer code.« less