Cell structure and proliferative activity of organ cultures of normal embryonic lung tissue of mice resistant (C57BL) and predisposed (A) to lung tumors

Journal Article · Thu Aug 01 00:00:00 EDT 1985 · Bull. Exp. Biol. Med. (Engl. Transl.); (United States)

DOI:https://doi.org/10.1007/BF00799082· OSTI ID:6958281

Kolesnichenko, T S; Gor'kova, T G

Local factors such as proliferative activity and the numerical ratio between epithelial and mesenchymal cells, and also the character of interaction between the tissue components in ontogeny may play an important role in the realization of sensitivity of mice of a particular line to the development of lung tumors. These characteristics of lung tissue in mice of lines A and C57BL are investigated under normal conditions and during induced carcinogenesis. Results are given of a comparative study of the relative numbers of epithelial and mesenchymal cells in organ cultures of embryonic lungs. /sup 3/H-thymidine was added to the cultures on the 14th day of the experiment in a concentration of 1 microCi/m1 medium. An autoradiographic study of the cultures was performed.

• Research Organization: All-Union Oncologic Scientific Center, Acad. of Medical Sci., Moscow
• OSTI ID: 6958281
• Journal Information: Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Vol. 99:3
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
EMBRYONIC CELLS
CARCINOGENESIS
CELL PROLIFERATION
RESPIRATORY TRACT CELLS
CARCINOMAS
CELL CULTURES
COMPARATIVE EVALUATIONS
CONNECTIVE TISSUE CELLS
EPITHELIUM
LUNGS
MICE
QUANTITY RATIO
TRACER TECHNIQUES
TRANSPLANTS
TRITIUM COMPOUNDS
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BODY
DISEASES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
NEOPLASMS
ORGANS
PATHOGENESIS
RESPIRATORY SYSTEM
RODENTS
SOMATIC CELLS
TISSUES
VERTEBRATES
550301* - Cytology- Tracer Techniques