Banding studies of chromosomal abnormalities in patients with acute lymphocytic leukemia

Journal Article · Mon Jan 01 00:00:00 EST 1979 · Cancer Res.; (United States)

OSTI ID:6942753

Cimino, M C ^[1]; Rowley, J D; Variakojis, D; Golomb, H M

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1. Univ. of Chicago, IL

Karyotypes were analyzed by routine Giemsa and quinacrine fluorescence for 16 patients with acute lymphocytic leukemia. Four patients had received previous therapy, but all 16 had active disease when they were first studied. All chromosomes except Nos. 3, 5, 15, 16, and Y were involved in the various aneuploidies. One patient had a Ph/sup 1/ chromosome due to a translocation with No. 21: t(21,22)(q22;q11). A patient with a B-cell acute lymphocytic leukemia had a 14q+ marker in addition to other abormalities. The median survival of patients with initially normal karyotypes may be longer than that of patients whose karyotypes are abnormal initially.

• OSTI ID: 6942753
• Journal Information: Cancer Res.; (United States), Vol. 39
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
BANDING TECHNIQUES
DIAGNOSTIC USES
CHROMOSOMAL ABERRATIONS
EVALUATION
KARYOTYPE
LEUKEMIA
PATIENTS
PHILADELPHIA CHROMOSOME
SURVIVAL TIME
CHROMOSOMES
DISEASES
HEMIC DISEASES
MUTATIONS
NEOPLASMS
USES
550900* - Pathology
550400 - Genetics