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Title: Immunological and biochemical effects of 60-Hz electric and magnetic fields in humans

Abstract

Public concern has been expressed about possible health risks arising from exposure to powerline electric and magnetic fields. This project is addressing this concern through a research program designed to evaluate the effects of exposure to known field conditions on multiple measures of human function. The present phase of project activities began in October 1985, and will end in September 1988. Two of the three tasks to be accomplished in this phase have now been completed. During the present reporting period, project staff designed and began preparations for Task 3. These plans were reviewed at the two project review meetings held in the present reporting period, and data collection on the Task 3 study is scheduled to begin in the next reporting period. Project goals during this reporting period were to: complete analysis of intermittent exposure study; attend the annual DOE/EPRI contractors review meeting; participate in project review meetings; and design and prepare for Task 3. Data collection for this study ended in the previous reporting period. The following activities were performed to complete the required statistical analyses: electrophysiological data were screened for artifacts, scored, and entered into the compute data base; urine samples were assayed for cortisol, dopamine, epinephrine,more » and norepinephrine; performance data were verified and entered into the data base; subjective data were verified and entered into the data base; and multivariate and univariate statistical tests were performed to evaluate the effects of the exposure conditions on the above measures.« less

Authors:
;
Publication Date:
Research Org.:
Midwest Research Inst., Kansas City, MO (USA)
Sponsoring Org.:
DOE/CE
OSTI Identifier:
6942499
Report Number(s):
DOE/CE/76246-T16
ON: DE90012557
DOE Contract Number:
FC01-84CE76246
Resource Type:
Technical Report
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 24 POWER TRANSMISSION AND DISTRIBUTION; ELECTROMAGNETIC FIELDS; BIOLOGICAL EFFECTS; MAN; HEALTH HAZARDS; ADRENALINE; CHRONIC EXPOSURE; ELECTRIC POWER; HUMAN POPULATIONS; NORADRENALINE; PHYSIOLOGY; POWER GENERATION; POWER TRANSMISSION LINES; PROGRESS REPORT; PUBLIC OPINION; STATISTICS; URINE; ADRENAL HORMONES; ANIMALS; AUTONOMIC NERVOUS SYSTEM AGENTS; BIOLOGICAL MATERIALS; BIOLOGICAL WASTES; BODY FLUIDS; CARDIOTONICS; CARDIOVASCULAR AGENTS; DOCUMENT TYPES; DRUGS; HAZARDS; MAMMALS; MATERIALS; MATHEMATICS; NEUROREGULATORS; POPULATIONS; POWER; PRIMATES; SYMPATHOMIMETICS; VERTEBRATES; WASTES; 560400* - Other Environmental Pollutant Effects; 240400 - Power Transmission & Distribution- Health & Safety- (1990-)

Citation Formats

Graham, C., and Cohen, H.D. Immunological and biochemical effects of 60-Hz electric and magnetic fields in humans. United States: N. p., 1988. Web.
Graham, C., & Cohen, H.D. Immunological and biochemical effects of 60-Hz electric and magnetic fields in humans. United States.
Graham, C., and Cohen, H.D. 1988. "Immunological and biochemical effects of 60-Hz electric and magnetic fields in humans". United States. doi:.
@article{osti_6942499,
title = {Immunological and biochemical effects of 60-Hz electric and magnetic fields in humans},
author = {Graham, C. and Cohen, H.D.},
abstractNote = {Public concern has been expressed about possible health risks arising from exposure to powerline electric and magnetic fields. This project is addressing this concern through a research program designed to evaluate the effects of exposure to known field conditions on multiple measures of human function. The present phase of project activities began in October 1985, and will end in September 1988. Two of the three tasks to be accomplished in this phase have now been completed. During the present reporting period, project staff designed and began preparations for Task 3. These plans were reviewed at the two project review meetings held in the present reporting period, and data collection on the Task 3 study is scheduled to begin in the next reporting period. Project goals during this reporting period were to: complete analysis of intermittent exposure study; attend the annual DOE/EPRI contractors review meeting; participate in project review meetings; and design and prepare for Task 3. Data collection for this study ended in the previous reporting period. The following activities were performed to complete the required statistical analyses: electrophysiological data were screened for artifacts, scored, and entered into the compute data base; urine samples were assayed for cortisol, dopamine, epinephrine, and norepinephrine; performance data were verified and entered into the data base; subjective data were verified and entered into the data base; and multivariate and univariate statistical tests were performed to evaluate the effects of the exposure conditions on the above measures.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = 1988,
month = 1
}

Technical Report:
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  • In order to meet rising energy demands, utility companies have increased both the number and the voltages employed in their overhead power transmission lines. Public concern has been expressed about possible risks to human health and function arising from the resulting increase in exposure to the electric and magnetic fields generated by such line. The present project is addressing these concerns by conducting a comprehensive research program to evaluate the effects of relevant electric and magnetic field exposure conditions on multiple measures of human function. This project is being conducted in two phases. Phase 1 was performed in cooperation withmore » the New York State Department of Health (NYSDH). Its purpose was to collect and analyze biochemical data from human subjects participating in the first comprehensive double-blind study of the effects of, exposure to combined 60 Hz electric and magnetic fields. Phase 2 is designed to accomplish three major tasks: perform additional statistical analysis of the data collected in the double-blind study; develop procedures to measure human physiology in active 60 Hz fields under double-blind control conditions; and conduct a study to validate the physiological measurement procedures, and to partially replicate the findings of the previous study.« less
  • Public concern has been expected about the potential health risks associated with exposure to electric and magnetic fields generated by overhead power transmission lines. This project is addressing these concerns through a research program designed to evaluate the effects of field exposure on multiple measures of human function. The major goal is to conduct a double-blind human exposure study to verify the findings obtained in the earlier screening study. The planned study will include: testing for exposure effects on a larger subject sample; the inclusion of pure-sham and pure-real exposure control groups; the collection of selected performance and electrophysiological measuresmore » before, during, and after exposure to real and sham fields; and the collection of selected biochemical measures at predetermined intervals. During this first reporting period, project goals were to: prepare a review of project findings and future plans for presentation at the 1985 DOE Contractors Review Meeting; prepare the required Phase 2 summary report for submission to DOE; hire and begin training of new staff to help perform the planned study; select all measures to be obtained in the planned study; complete computer programming/pilot testing activities required to implement data collection for the selected measures, and prepare a detailed experimental protocol; and begin subject recruitment. 1 tab.« less
  • Demand for electric power increased at an annual average rate of 7.5% between 1912 and 1971. In order to meet this demand, utility companies have had to increase both the number and the operating voltages employed in their overhead transmission lines. Public concern has been expressed about possible risks to human health and function arising from exposure to the electric and magnetic fields generated by these lines. The New York State Department of Health (NYSDH) is currently administering a wide-ranging research program to address the above issues. As part of this effort, MRI was funded to perform the first double-blindmore » human study of the effects of exposure to combined 60-Hz electric and magnetic fields. The study focused on measure of human performance physiology and subjective state. The present project into the planned double-blind study. The purpose of Phase 1 was to conduct a comprehensive, screening evaluation of the effects of field exposure on human immunologic hematologic and biochemical parameters. Phase 1 of the current program has now also been completed, and the purpose of this report is to summarize our findings in regard to the effects of field exposure on measures of human immunologic, hematologic and biochemical function. The following sections of this document present the specific aims of the research conducted, the experimental methods and procedures followed, and the statistical analysis performed. The document concludes with a discussion of the findings obtained.« less
  • Public concern is growing about the possible health risks of exposure to the electric and magnetic fields generated by power distribution systems. This research program is evaluating whether field exposure results in specific and replicable effects on measures of human performance, physiology, biochemistry, and subjective state. The studies reported here were performed under controlled laboratory conditions in the Human Exposure Test Facility at Midwest Research Institute (MRI). 80 refs., 13 figs., 6 tabs.
  • Demand for electric energy increased at an annual average rate of 7.5% between 1912 and 1971. In order to meet this demand, utility companies have increased the number and size of their generating units and the operating voltages employed in overhead transmission lines. Recently, public concern has been expressed about possible risks to human health, function, and well-being arising from exposure to the electric and magnetic fields associated with overhead transmission line voltages. The Department of Energy funded the present project to investigate the effects of 60-Hz electric and magnetic fields on critically important immunological, biochemical, and hematological variables. Inclusionmore » of such variables will be of great value in assessing the effects of 60-Hz fields on human health and welfare, and will provide results comparable to ongoing animal studies. The scope of this project includes six major goals: development of systems for incorporating biochemistry, hematology, and immunology data collection into the procedures already developed for the performance and physiology study funded by the New York State Overhead Power Lines Project; development of sample tracking and quality assurance procedures for project data; methods develop and setting up of all procedures for performing assays; collecting data; carrying out assays according to the procedures defined; and statistically evaluating and interpreting the effects of 60-Hz exposure on hematological, biochemical, and immunological parameters. 1 tab.« less