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Title: The revascularization of pedicle skin flaps in pigs: a functional and morphologic study

Abstract

Functional and morphologic changes occurring during the revascularization of pedicle flaps have been investigated in the skin of pigs. The skin flaps, 16 cm long by 4 cm wide, were based on a row of segmental vessels arising from the internal mammary artery. Comparative measurements were made in flapped and normal skin. The inherent blood supply in the pedicle of the flap was unable to maintain the whole of the flap in a viable state. Flap viability was ascertained at surgery by the use of the intravital dye Disulphine blue. Injections of the dye after surgery gave a less accurate prediction of viability than when dye was injected prior to surgery. Revascularization between the flap and surrounding skin was evident 3 to 4 days postoperatively at the distal, most hypoxic part of the viable flap. The whole flap had a collateral vascular supply 7 to 10 days after surgery. Isotope clearance studies showed that the greatest functional changes occurred in the distal third of the viable flap, where, after initially slowing, the clearance rate became faster than in normal skin (day 5). Potassium extraction studies indicated similar changes. However, an increase in the red-cell volume on day 1 suggested thatmore » vascular shunting was occurring. The results of the morphologic studies indicated a correlation between the number of blood vessels per unit area, the thickness of the dermis, and the recorded functional changes. Seven days after surgery, when isotope clearance rates were very rapid, there was a significant increase in the vascular density and dermal thickness.« less

Authors:
Publication Date:
Research Org.:
Churchill Hospital Research Institute at the University of Oxford
OSTI Identifier:
6942428
Resource Type:
Journal Article
Resource Relation:
Journal Name: Plast. Reconstr. Surg.; (United States); Journal Volume: 70:4
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; BLOOD VESSELS; BIOLOGICAL REGENERATION; GRAFTS; VIABILITY; ISOTOPE APPLICATIONS; MORPHOLOGICAL CHANGES; MORPHOLOGY; RADIOISOTOPES; SKIN; SWINE; ANIMALS; BIOLOGICAL RECOVERY; BODY; CARDIOVASCULAR SYSTEM; DOMESTIC ANIMALS; ISOTOPES; MAMMALS; ORGANS; RECOVERY; TRANSPLANTS; VERTEBRATES; 551001* - Physiological Systems- Tracer Techniques; 550801 - Morphology- Tracer Techniques

Citation Formats

Young, C.M. The revascularization of pedicle skin flaps in pigs: a functional and morphologic study. United States: N. p., 1982. Web. doi:10.1097/00006534-198210000-00008.
Young, C.M. The revascularization of pedicle skin flaps in pigs: a functional and morphologic study. United States. doi:10.1097/00006534-198210000-00008.
Young, C.M. Fri . "The revascularization of pedicle skin flaps in pigs: a functional and morphologic study". United States. doi:10.1097/00006534-198210000-00008.
@article{osti_6942428,
title = {The revascularization of pedicle skin flaps in pigs: a functional and morphologic study},
author = {Young, C.M.},
abstractNote = {Functional and morphologic changes occurring during the revascularization of pedicle flaps have been investigated in the skin of pigs. The skin flaps, 16 cm long by 4 cm wide, were based on a row of segmental vessels arising from the internal mammary artery. Comparative measurements were made in flapped and normal skin. The inherent blood supply in the pedicle of the flap was unable to maintain the whole of the flap in a viable state. Flap viability was ascertained at surgery by the use of the intravital dye Disulphine blue. Injections of the dye after surgery gave a less accurate prediction of viability than when dye was injected prior to surgery. Revascularization between the flap and surrounding skin was evident 3 to 4 days postoperatively at the distal, most hypoxic part of the viable flap. The whole flap had a collateral vascular supply 7 to 10 days after surgery. Isotope clearance studies showed that the greatest functional changes occurred in the distal third of the viable flap, where, after initially slowing, the clearance rate became faster than in normal skin (day 5). Potassium extraction studies indicated similar changes. However, an increase in the red-cell volume on day 1 suggested that vascular shunting was occurring. The results of the morphologic studies indicated a correlation between the number of blood vessels per unit area, the thickness of the dermis, and the recorded functional changes. Seven days after surgery, when isotope clearance rates were very rapid, there was a significant increase in the vascular density and dermal thickness.},
doi = {10.1097/00006534-198210000-00008},
journal = {Plast. Reconstr. Surg.; (United States)},
number = ,
volume = 70:4,
place = {United States},
year = {Fri Oct 01 00:00:00 EDT 1982},
month = {Fri Oct 01 00:00:00 EDT 1982}
}