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Title: Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse

Abstract

Cyclic nucleotides are important second messengers that mediate a number of cellular responses to external signals. Cyclic nucleotide phosphodiesterases play a role in signal transduction by regulating the cellular concentrations of these messengers. Here, the authors have applied Southern analyses of somatic cell hybrid lines and of recombinant inbred (RI) mouse strains as well as fluorescence chromosomal in situ hybridization (FISH) to chromosomally localize five cAMP-specific nucleotide phosphodiesterase genes in human and mouse. Genes DPDE1, DPDE2, DPDE3, and DPDE4 that share sequence homology with the Drosophila dunce gene were assigned to human chromosomes 19 (DPDE1 and DPDE2), ga12 (DPDE3), and 1p31 (DPDE4) and to mouse chromosomes 8, 9, 13, and 4, respectively. The high-affinity cAMP-specific phosphodiesterase gene (HCP1) was mapped to human chromosome 8q13-q22. Since these genes are potential candidates for involvement in psychiatric or behavioral disorders, knowledge of their chromosomal localizations will facilitate the discovery of their association with disease genes as they are being mapped by linkage studies.

Authors:
;  [1]; ;  [2]
  1. (Stanford Univ. Medical Center, CA (United States))
  2. (Cold Spring Harbor Lab., NY (United States))
Publication Date:
OSTI Identifier:
6940728
Resource Type:
Journal Article
Journal Name:
Somatic Cell and Molecular Genetics; (United States)
Additional Journal Information:
Journal Volume: 20:2; Journal ID: ISSN 0740-7750
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; HUMAN CHROMOSOMES; GENETIC MAPPING; PHOSPHODIESTERASES; GENES; AMP; DNA HYBRIDIZATION; HUMAN CHROMOSOME 1; HUMAN CHROMOSOME 12; HUMAN CHROMOSOME 19; HUMAN CHROMOSOME 8; BIOTECHNOLOGY; CHROMOSOMES; ENZYMES; ESTERASES; GENETIC ENGINEERING; HYBRIDIZATION; HYDROLASES; MAPPING; NUCLEIC ACID HYBRIDIZATION; NUCLEOTIDES; ORGANIC COMPOUNDS; PROTEINS; 550400* - Genetics

Citation Formats

Milatovich, A., Francke, U., Bolger, G., and Michaeli, T. Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse. United States: N. p., 1994. Web. doi:10.1007/BF02290677.
Milatovich, A., Francke, U., Bolger, G., & Michaeli, T. Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse. United States. doi:10.1007/BF02290677.
Milatovich, A., Francke, U., Bolger, G., and Michaeli, T. Tue . "Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse". United States. doi:10.1007/BF02290677.
@article{osti_6940728,
title = {Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse},
author = {Milatovich, A. and Francke, U. and Bolger, G. and Michaeli, T.},
abstractNote = {Cyclic nucleotides are important second messengers that mediate a number of cellular responses to external signals. Cyclic nucleotide phosphodiesterases play a role in signal transduction by regulating the cellular concentrations of these messengers. Here, the authors have applied Southern analyses of somatic cell hybrid lines and of recombinant inbred (RI) mouse strains as well as fluorescence chromosomal in situ hybridization (FISH) to chromosomally localize five cAMP-specific nucleotide phosphodiesterase genes in human and mouse. Genes DPDE1, DPDE2, DPDE3, and DPDE4 that share sequence homology with the Drosophila dunce gene were assigned to human chromosomes 19 (DPDE1 and DPDE2), ga12 (DPDE3), and 1p31 (DPDE4) and to mouse chromosomes 8, 9, 13, and 4, respectively. The high-affinity cAMP-specific phosphodiesterase gene (HCP1) was mapped to human chromosome 8q13-q22. Since these genes are potential candidates for involvement in psychiatric or behavioral disorders, knowledge of their chromosomal localizations will facilitate the discovery of their association with disease genes as they are being mapped by linkage studies.},
doi = {10.1007/BF02290677},
journal = {Somatic Cell and Molecular Genetics; (United States)},
issn = {0740-7750},
number = ,
volume = 20:2,
place = {United States},
year = {1994},
month = {3}
}