Immunolymphoscintigraphy and immunoscintigraphy of ovarian and fallopian tube cancer using F(ab')2 fragments of monoclonal antibody OC 125
- Helsinki Univ. Central Hospital (Finland)
We have used immunolymphoscintigraphy (ILS) alone or in combination with immunoscintigraphy with {sup 131}I-labeled F(ab')2 fragments of monoclonal OC 125 antibodies to improve detection of retroperitoneal lymph node metastases of ovarian and fallopian tube cancer. ILS was carried out with bilateral dorsopedal s.c. injections on nine patients and with bilateral iliopelvic injections into the ischiorectal fossa on two other patients. Radioimaging was performed 2-4 times between 0 and 5 days. An additional dose of labeled antibody fragments was given i.v., and imaging was done 2-3 days later. Conventional immunoscintigraphy without preceding ILS was carried out on another nine patients. Dorsopedal ILS improved detection of pelvic and paraaortic lymph node metastases. Malignant lymph nodes were detectable as early as 3 h after s.c. injection of the tracer. Combined results of ILS and immunoscintigraphy in 16 surgically verified cases indicated a true positive finding in 9 patients, true negative finding in 5, false positive in one, and false negative in 1. Calculated from these figures the sensitivity, specificity, and accuracy of the method were 90, 83, and 88%, respectively. Involved lymph nodes were found more frequently in those patients whose serum CA 125 concentration was elevated demonstrating that an elevated serum CA 125 level does not preclude successful radioimmunodetection.
- OSTI ID:
- 6939067
- Journal Information:
- Cancer Research; (USA), Vol. 50; ISSN 0008-5472
- Country of Publication:
- United States
- Language:
- English
Similar Records
Immunolymphoscintigraphy and the dose dependence of /sup 111/In-labeled T101 monoclonal antibody in patients with cutaneous T-cell lymphoma
Radioimmunodetection of lymph node invasion in prostatic cancer. The use of iodine-123 ( sup 123 I)-labeled monoclonal anti-prostatic acid phosphatase (PAP) 227 A F(ab')2 antibody fragments in vivo
Related Subjects
LYMPH NODES
METASTASES
DIAGNOSIS
OVARIES
NEOPLASMS
RADIOIMMUNOSCINTIGRAPHY
ACCURACY
IMMUNOGLOBULINS
IODINE 131
MONOCLONAL ANTIBODIES
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
FEMALE GENITALS
GLOBULINS
GONADS
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LYMPHATIC SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIOIMMUNODETECTION
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
TRACER TECHNIQUES
550601* - Medicine- Unsealed Radionuclides in Diagnostics