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Title: Nuclear Medicine Program progress report for quarter ending June 30, 1990

Abstract

In this a report novel electrochemical method is described for the separation of copper-64 and copper-67 following the irradiation of zinc targets. This method is based on the spontaneous electrodeposition of copper on a platinum electrode immersed in the zinc target solution without requiring an external electromotive force (EMF). No-carrier-added N-(2-(3-({sup 125}I)iodo-4-hydroxyphenyl)ethyl)-maleimide has been prepared by direct iodination of N-(2-(4-hydroxyphenyl)ethyl)-maleimide with (Na({sup 125}I)-chloramine-T). The precursor was prepared by condensation of tyramine with maleic anhydride followed by ring annulation. Studies in rats showed low thyroid uptake of radioactivity which reached a plateau after 4 h, indicating in vivo stability. This new radioiodinated maleimide analogue reacts with bovine serum albumin (BSA) under mild conditions and has been used for labeling a lung-endothelial-cell-specific antibody (411-201B). The ({sup 125}I)-labeled antibodies are currently being evaluated for immunoreactivity and tumor specificity. During this period several agents were also supplied to Medical Cooperative investigators, including iodine-123-labeled and iodine-131-labeled fatty acid analogues for studies at the Brookhaven National Laboratory, the Cardiology Department at the Free University of Amsterdam, and the University of Bonn, West Germany. A tungsten-188/rhenium-188 generator was supplied to the University of Massachusetts, and osmium-191 was supplied for fabrication of generators for patient studies in Finland.more » 4 refs., 5 figs., 5 tabs.« less

Authors:
; ; ; ; ; ; ; ; ; ;
Publication Date:
Research Org.:
Oak Ridge National Lab., TN (USA)
Sponsoring Org.:
DOE/ER
OSTI Identifier:
6939010
Report Number(s):
ORNL/TM-11570
ON: DE90016681
DOE Contract Number:  
AC05-84OR21400
Resource Type:
Technical Report
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ANTIBODIES; LABELLING; CHLORAMINES; IODINATION; COPPER; ELECTRODEPOSITION; COPPER 67; MONOCARBOXYLIC ACIDS; NEOPLASMS; RADIOIMMUNOTHERAPY; ALBUMINS; AQUEOUS SOLUTIONS; BIOLOGICAL EFFECTS; ELECTROCHEMISTRY; IODINE 123; IODINE 131; LARGE INTESTINE; LUNGS; NUCLEAR MEDICINE; PROGRESS REPORT; RADIOPHARMACEUTICALS; RATS; RHENIUM 188; SPECIFICITY; TUNGSTEN 188; AMINES; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARBOXYLIC ACIDS; CHEMICAL REACTIONS; CHEMISTRY; COPPER ISOTOPES; DAYS LIVING RADIOISOTOPES; DEPOSITION; DIGESTIVE SYSTEM; DISEASES; DISPERSIONS; DOCUMENT TYPES; DRUGS; ELECTROLYSIS; ELECTRON CAPTURE RADIOISOTOPES; ELEMENTS; EVEN-EVEN NUCLEI; GASTROINTESTINAL TRACT; HALOGENATION; HEAVY NUCLEI; HOURS LIVING RADIOISOTOPES; IMMUNOLOGY; IMMUNOTHERAPY; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; INTESTINES; IODINE ISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LYSIS; MAMMALS; MEDICINE; METALS; MINUTES LIVING RADIOISOTOPES; MIXTURES; NUCLEI; ODD-EVEN NUCLEI; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC CHLORINE COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANS; PROTEINS; RADIOIMMUNOLOGY; RADIOISOTOPES; RADIOLOGY; RADIOTHERAPY; RESPIRATORY SYSTEM; RHENIUM ISOTOPES; RODENTS; SOLUTIONS; SURFACE COATING; THERAPY; TRANSITION ELEMENTS; TUNGSTEN ISOTOPES; VERTEBRATES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 550604 - Medicine- Unsealed Radionuclides in Therapy- (1980-)

Citation Formats

Knapp, Jr, F F, Ambrose, K R, Callahan, A P, McPherson, D W, Mirzadeh, S, Srivastava, P C, Allred, J F, Hasan, A, Lambert, C R, Lambert, S J, and Rice, D E. Nuclear Medicine Program progress report for quarter ending June 30, 1990. United States: N. p., 1990. Web.
Knapp, Jr, F F, Ambrose, K R, Callahan, A P, McPherson, D W, Mirzadeh, S, Srivastava, P C, Allred, J F, Hasan, A, Lambert, C R, Lambert, S J, & Rice, D E. Nuclear Medicine Program progress report for quarter ending June 30, 1990. United States.
Knapp, Jr, F F, Ambrose, K R, Callahan, A P, McPherson, D W, Mirzadeh, S, Srivastava, P C, Allred, J F, Hasan, A, Lambert, C R, Lambert, S J, and Rice, D E. Wed . "Nuclear Medicine Program progress report for quarter ending June 30, 1990". United States.
@article{osti_6939010,
title = {Nuclear Medicine Program progress report for quarter ending June 30, 1990},
author = {Knapp, Jr, F F and Ambrose, K R and Callahan, A P and McPherson, D W and Mirzadeh, S and Srivastava, P C and Allred, J F and Hasan, A and Lambert, C R and Lambert, S J and Rice, D E},
abstractNote = {In this a report novel electrochemical method is described for the separation of copper-64 and copper-67 following the irradiation of zinc targets. This method is based on the spontaneous electrodeposition of copper on a platinum electrode immersed in the zinc target solution without requiring an external electromotive force (EMF). No-carrier-added N-(2-(3-({sup 125}I)iodo-4-hydroxyphenyl)ethyl)-maleimide has been prepared by direct iodination of N-(2-(4-hydroxyphenyl)ethyl)-maleimide with (Na({sup 125}I)-chloramine-T). The precursor was prepared by condensation of tyramine with maleic anhydride followed by ring annulation. Studies in rats showed low thyroid uptake of radioactivity which reached a plateau after 4 h, indicating in vivo stability. This new radioiodinated maleimide analogue reacts with bovine serum albumin (BSA) under mild conditions and has been used for labeling a lung-endothelial-cell-specific antibody (411-201B). The ({sup 125}I)-labeled antibodies are currently being evaluated for immunoreactivity and tumor specificity. During this period several agents were also supplied to Medical Cooperative investigators, including iodine-123-labeled and iodine-131-labeled fatty acid analogues for studies at the Brookhaven National Laboratory, the Cardiology Department at the Free University of Amsterdam, and the University of Bonn, West Germany. A tungsten-188/rhenium-188 generator was supplied to the University of Massachusetts, and osmium-191 was supplied for fabrication of generators for patient studies in Finland. 4 refs., 5 figs., 5 tabs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1990},
month = {8}
}

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