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Title: Prior exposure to ozone potentiates subsequent response to sulfur dioxide in adolescent asthmatic subjects

Abstract

The objective of this study was to test whether prior exposure to a low concentration of ozone (120 ppb) would condition airways in asthmatic subjects to respond to a subthreshold concentration of sulfur dioxide (100 ppb). Eight male and five female subjects 12 to 18 yr of age participated. They all had allergic asthma and exercise-induced bronchospasm. Subjects were exposed to three test atmosphere sequences during intermittent moderate exercise (a 45-min exposure to one pollutant followed by a 15-min exposure to the second pollutant). The sequences were: air followed by 100 ppb SO2, 120 ppb O3 followed by 120 ppb O3, and 120 ppb O3 followed by 100 ppb SO2. The pulmonary function measurements assessed were FEV1, total respiratory resistance (RT), and maximal flow (Vmax50). Air-SO2 and O3-O3 exposures did not cause significant changes in pulmonary function. On the other hand, exposure to 100 ppb SO2 after a 45-min exposure to 120 ppb O3 caused a significant (8%) decrease in FEV1 (p = 0.046), a significant (19%) increase in RT (p = 0.048), and a significant (15%) decrease in Vmax50 (p = 0.008). It is concluded that prior O3 exposure increased bronchial hyperresponsiveness in these subjects such that they respondedmore » to an ordinarily subthreshold concentration of SO2. These data suggest that assessment of pulmonary changes to single pollutant challenges overlooks the interactive effects of common coexisting or sequentially occurring air pollutants.« less

Authors:
; ; ; ;  [1]
  1. (Univ. of Washington, Seattle (USA))
Publication Date:
OSTI Identifier:
6936567
Resource Type:
Journal Article
Resource Relation:
Journal Name: American Review of Respiratory Disease (New York); (USA); Journal Volume: 141:2
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ASTHMA; PATHOGENESIS; OZONE; TOXICITY; SULFUR DIOXIDE; AIR POLLUTION; DOSE-RESPONSE RELATIONSHIPS; ENVIRONMENTAL EXPOSURE; EXERCISE; LUNGS; MAN; SYNERGISM; ANIMALS; BODY; CHALCOGENIDES; DISEASES; MAMMALS; ORGANS; OXIDES; OXYGEN COMPOUNDS; POLLUTION; PRIMATES; RESPIRATORY SYSTEM; RESPIRATORY SYSTEM DISEASES; SULFUR COMPOUNDS; SULFUR OXIDES; VERTEBRATES; 560300* - Chemicals Metabolism & Toxicology

Citation Formats

Koenig, J.Q., Covert, D.S., Hanley, Q.S., van Belle, G., and Pierson, W.E. Prior exposure to ozone potentiates subsequent response to sulfur dioxide in adolescent asthmatic subjects. United States: N. p., 1990. Web. doi:10.1164/ajrccm/141.2.377.
Koenig, J.Q., Covert, D.S., Hanley, Q.S., van Belle, G., & Pierson, W.E. Prior exposure to ozone potentiates subsequent response to sulfur dioxide in adolescent asthmatic subjects. United States. doi:10.1164/ajrccm/141.2.377.
Koenig, J.Q., Covert, D.S., Hanley, Q.S., van Belle, G., and Pierson, W.E. Thu . "Prior exposure to ozone potentiates subsequent response to sulfur dioxide in adolescent asthmatic subjects". United States. doi:10.1164/ajrccm/141.2.377.
@article{osti_6936567,
title = {Prior exposure to ozone potentiates subsequent response to sulfur dioxide in adolescent asthmatic subjects},
author = {Koenig, J.Q. and Covert, D.S. and Hanley, Q.S. and van Belle, G. and Pierson, W.E.},
abstractNote = {The objective of this study was to test whether prior exposure to a low concentration of ozone (120 ppb) would condition airways in asthmatic subjects to respond to a subthreshold concentration of sulfur dioxide (100 ppb). Eight male and five female subjects 12 to 18 yr of age participated. They all had allergic asthma and exercise-induced bronchospasm. Subjects were exposed to three test atmosphere sequences during intermittent moderate exercise (a 45-min exposure to one pollutant followed by a 15-min exposure to the second pollutant). The sequences were: air followed by 100 ppb SO2, 120 ppb O3 followed by 120 ppb O3, and 120 ppb O3 followed by 100 ppb SO2. The pulmonary function measurements assessed were FEV1, total respiratory resistance (RT), and maximal flow (Vmax50). Air-SO2 and O3-O3 exposures did not cause significant changes in pulmonary function. On the other hand, exposure to 100 ppb SO2 after a 45-min exposure to 120 ppb O3 caused a significant (8%) decrease in FEV1 (p = 0.046), a significant (19%) increase in RT (p = 0.048), and a significant (15%) decrease in Vmax50 (p = 0.008). It is concluded that prior O3 exposure increased bronchial hyperresponsiveness in these subjects such that they responded to an ordinarily subthreshold concentration of SO2. These data suggest that assessment of pulmonary changes to single pollutant challenges overlooks the interactive effects of common coexisting or sequentially occurring air pollutants.},
doi = {10.1164/ajrccm/141.2.377},
journal = {American Review of Respiratory Disease (New York); (USA)},
number = ,
volume = 141:2,
place = {United States},
year = {Thu Feb 01 00:00:00 EST 1990},
month = {Thu Feb 01 00:00:00 EST 1990}
}