Reversible cold-induced abnormalities in myocardial perfusion and function in systemic sclerosis
The effects of peripheral cold exposure on myocardial perfusion and function were studied in 13 patients with scleroderma without clinically evident myocardial disease. Ten patients had at least one transient, cold-induced, myocardial perfusion defect visualized by thallium-201 scintigraphy, and 12 had reversible, cold-induced, segmental left ventricular hypokinesis by two-dimensional echocardiography. The 10 patients with transient perfusion defects all had anatomically corresponding ventricular wall motion abnormalities. No one in either of two control groups (9 normal volunteers and 7 patients with chest pain and normal coronary arteriograms) had cold-induced abnormalities. This study is the first to show the simultaneous occurrence of cold-induced abnormalities in myocardial perfusion and function in patients with scleroderma. The results suggest that cold exposure in such patients may elicit transient reflex coronary vasoconstriction resulting in reversible myocardial ischemia and dysfunction. Chronic recurrent episodes of coronary spasm may lead to focal myocardial fibrosis.
- Research Organization:
- Johns Hopkins Medical Institutions, Baltimore, MD
- OSTI ID:
- 6935525
- Journal Information:
- Ann. Intern. Med.; (United States), Vol. 5
- Country of Publication:
- United States
- Language:
- English
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MYOCARDIUM
SCINTISCANNING
TEMPERATURE EFFECTS
BLOOD PRESSURE
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PERFUSED ORGANS
THALLIUM 201
BETA DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR SYSTEM
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DAYS LIVING RADIOISOTOPES
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ISOMERIC TRANSITION ISOTOPES
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RADIOISOTOPE SCANNING
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SECONDS LIVING RADIOISOTOPES
THALLIUM ISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics