Chemical hazard information profile of triphenyl phosphite
The only human study located showed that triphenyl phosphite applied to the skin in a 1:3 dilution with cold cream for 48 h caused slight irritation, and challenge with the compound 14 days later produced a moderate sensitization reaction. The most significant health effects described in experimental animals are those affecting the nervous system. In adult rats, subacute exposure to the chemical produced gross ataxia and spinal cord neuropathy which predominantly affected the lateral and ventral columns of the lumber and sacral regions. Other symptoms included hyperexcitability and agitation after several days, muscle wasting, asymmetric gait, and hind-limb paralysis. All animals developed tail rigidity with a kinky appearance, and some animals displayed a circling behavior. The compound appeared to only weakly inhibit acetylcholinesterase activity. Single oral doses of triphenyl phosphite Gallus domesticus produced ataxia, and spinal cord and peripheral nerve histopathology. Neurotoxicity in rats, cats, and chickens indicated that triphenyl phosphite caused two distinct stages of action. Rats given s.c. injections of the chemical exhibit rapidly-developing stage or fine or coarse tremors which disappeared after a few hours. The later stage, occurring several days after treatment, caused hyperexcitability, spasticity and incoordination, followed by partial flaccid paralysis of the extremities. 135 refs., 2 tabs.
- Research Organization:
- Oak Ridge National Lab., TN (USA)
- DOE Contract Number:
- AC05-84OR21400
- OSTI ID:
- 6935051
- Report Number(s):
- ORNL-6347; ON: DE87005378
- Country of Publication:
- United States
- Language:
- English
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PHOSPHORIC ACID ESTERS
BIOLOGICAL EFFECTS
CHICKENS
ENVIRONMENTAL IMPACTS
HEALTH HAZARDS
NERVOUS SYSTEM
OCCUPATIONAL EXPOSURE
ORAL ADMINISTRATION
RATS
REVIEWS
SKIN ABSORPTION
TOXICITY
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BIRDS
DOCUMENT TYPES
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560300* - Chemicals Metabolism & Toxicology