Measurement of regional pulmonary blood volume in patients with increased pulmonary blood flow or pulmonary arterial hypertension
The effects of chronic increase in pulmonary blood flow and chronic pulmonary hypertension on regional pulmonary blood volume was measured in two groups of patients. One group of patients had intracardiac, left-to-right shunts without appreciable pulmonary hypertension, and the other consisted of patients with Eisenmenger's syndrome or primary pulmonary hypertension, i.e. patients with normal or reduced blood flow and severe pulmonary hypertension. A technique based on positron tomography was used to measure lung density (by transmission scanning) and regional pulmonary blood volume (after inhalation of /sup 11/CO). The distribution of pulmonary blood volume was more uniform in patients with chronic increase in pulmonary blood flow than in normal subjects. There were also indications of an absolute increase in intrapulmonary blood volume by about 15%. In patients with chronic pulmonary arterial hypertension, the distribution of pulmonary blood volume was also abnormally uniform. There was, however, no indication that overall intrapulmonary blood volume was substantially different from normal subjects. The abnormally uniform distribution of pulmonary blood volume can be explained by recruitment and/or dilatation of vascular beds. Intrapulmonary blood volume appears to be increased in patients with intracardiac, left-to-right shunts. With the development of pulmonary hypertension, intrapulmonary blood volume falls, which may be explained by reactive changes in the vasculature and/or obliteration of capillaries.
- Research Organization:
- MRC Cyclotron Unit, Hammersmith Hospital, London
- OSTI ID:
- 6930173
- Report Number(s):
- CONF-840619-
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 25:5; Conference: 31. annual meeting of the Society of Nuclear Medicine, Los Angeles, CA, USA, 5 Jun 1984
- Country of Publication:
- United States
- Language:
- English
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HYPERTENSION
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RADIOISOTOPE SCANNING
ARTERIES
CAPILLARIES
CARBON MONOXIDE
DENSITY
INHALATION
PATIENTS
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COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
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EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
INTAKE
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LIGHT NUCLEI
MINUTES LIVING RADIOISOTOPES
NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
PHYSICAL PROPERTIES
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RESPIRATORY SYSTEM
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VASCULAR DISEASES
550602* - Medicine- External Radiation in Diagnostics- (1980-)
550601 - Medicine- Unsealed Radionuclides in Diagnostics