In vitro generation of helper T cells and suppressor T cells that regulate the cytolytic T lymphocyte response to trinitrophenyl-modified syngeneic cells
Helper T cells and suppressor T cells have been generated in vitro that regulate the cytolytic T lymphocyte (CTL) response to trinitrophenyl (TNP)-modified syngeneic cells. B6D2F1 helper cells generated to TNP-modified parental (P1) cells augment the CTL response to those P1-TNP-modified antigens but not to P2-TNP-modified antigens. The generation of these helper T cells requires the presence of splenic adherent cells and these helper T cells are radioresistant. A soluble factor can be obtained from the helper T cell cultures that can also augment the CTL response. The suppressor T cells generated in culture do not demonstrate the specificity observed with the helper T cells; however, they are antigen-dependent in their induction. Whether helper or suppressor activity is obtained depends upon the length of time cells are cultured in vitro.
- Research Organization:
- Department of Pathology, Sidney Farber Cencer Institute, Boston, MA
- OSTI ID:
- 6929189
- Journal Information:
- Transplantation; (United States), Vol. 33:4
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
IMMUNITY
PHYSIOLOGY
LYMPHOCYTES
RADIOSENSITIVITY
ANTIGENS
CELL CULTURES
PICRIC ACID
SPLEEN CELLS
ANIMAL CELLS
AROMATICS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHEMICAL EXPLOSIVES
CONNECTIVE TISSUE CELLS
EXPLOSIVES
HYDROXY COMPOUNDS
LEUKOCYTES
MATERIALS
NITRO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PHENOLS
SOMATIC CELLS
560121* - Radiation Effects on Cells- External Source- (-1987)
551000 - Physiological Systems