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Title: Evaluation of muscular lesions in connective tissue diseases: thallium 201 muscular scans

Abstract

We performed thallium 201 muscle scans to assess muscular involvement in 40 patients with different connective tissue diseases (7 with dermatomyositis, 7 with systemic lupus erythematosus, 12 with progressive systemic scleroderma, 2 with calcinosis, Raynaud's phenomenon, esophageal involvement, sclerodactyly, and telangiectasia (CREST) syndrome, 3 with monomelic scleroderma, 6 with morphea, and 3 with Raynaud's disease). Only 12 of these patients complained of fatigability and/or myalgia. Electromyography was performed and serum levels of muscle enzymes were measured in all patients. Comparison of thallium 201 exercise recording with the other tests revealed that scan sensitivity is greater than electromyographic and serum muscle enzymes levels. Thallium 201 scans showed abnormal findings in 32 patients and revealed subclinical lesions in 18 patients, while electromyography findings were abnormal in 25 of these 32 patients. Serum enzyme levels were raised in only 8 patients. Thallium 201 scanning proved to be a useful guide for modifying therapy when laboratory data were conflicting. It was useful to evaluate treatment efficacy. Because our data indicate a 100% positive predictive value, we believe that thallium 201 scanning should be advised for severe systemic connective tissue diseases with discordant test results.

Authors:
; ; ; ; ;
Publication Date:
Research Org.:
Dept. of Dermatology, CHU, Brest (France)
OSTI Identifier:
6924126
Alternate Identifier(s):
OSTI ID: 6924126
Resource Type:
Journal Article
Journal Name:
J. Am. Acad. Dermatol.; (United States)
Additional Journal Information:
Journal Volume: 18
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; MUSCLES; RADIOISOTOPE SCANNING; SKIN DISEASES; DIAGNOSIS; ENZYMES; EXERCISE; PATIENTS; THALLIUM 201; BETA DECAY RADIOISOTOPES; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; HEAVY NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; NUCLEI; ODD-EVEN NUCLEI; RADIOISOTOPES; SECONDS LIVING RADIOISOTOPES; THALLIUM ISOTOPES 550601* -- Medicine-- Unsealed Radionuclides in Diagnostics

Citation Formats

Guillet, G., Guillet, J., Sanciaume, C., Maleville, J., Geniaux, M., and Morin, P. Evaluation of muscular lesions in connective tissue diseases: thallium 201 muscular scans. United States: N. p., 1988. Web. doi:10.1016/S0190-9622(88)70087-0.
Guillet, G., Guillet, J., Sanciaume, C., Maleville, J., Geniaux, M., & Morin, P. Evaluation of muscular lesions in connective tissue diseases: thallium 201 muscular scans. United States. doi:10.1016/S0190-9622(88)70087-0.
Guillet, G., Guillet, J., Sanciaume, C., Maleville, J., Geniaux, M., and Morin, P. Fri . "Evaluation of muscular lesions in connective tissue diseases: thallium 201 muscular scans". United States. doi:10.1016/S0190-9622(88)70087-0.
@article{osti_6924126,
title = {Evaluation of muscular lesions in connective tissue diseases: thallium 201 muscular scans},
author = {Guillet, G. and Guillet, J. and Sanciaume, C. and Maleville, J. and Geniaux, M. and Morin, P.},
abstractNote = {We performed thallium 201 muscle scans to assess muscular involvement in 40 patients with different connective tissue diseases (7 with dermatomyositis, 7 with systemic lupus erythematosus, 12 with progressive systemic scleroderma, 2 with calcinosis, Raynaud's phenomenon, esophageal involvement, sclerodactyly, and telangiectasia (CREST) syndrome, 3 with monomelic scleroderma, 6 with morphea, and 3 with Raynaud's disease). Only 12 of these patients complained of fatigability and/or myalgia. Electromyography was performed and serum levels of muscle enzymes were measured in all patients. Comparison of thallium 201 exercise recording with the other tests revealed that scan sensitivity is greater than electromyographic and serum muscle enzymes levels. Thallium 201 scans showed abnormal findings in 32 patients and revealed subclinical lesions in 18 patients, while electromyography findings were abnormal in 25 of these 32 patients. Serum enzyme levels were raised in only 8 patients. Thallium 201 scanning proved to be a useful guide for modifying therapy when laboratory data were conflicting. It was useful to evaluate treatment efficacy. Because our data indicate a 100% positive predictive value, we believe that thallium 201 scanning should be advised for severe systemic connective tissue diseases with discordant test results.},
doi = {10.1016/S0190-9622(88)70087-0},
journal = {J. Am. Acad. Dermatol.; (United States)},
number = ,
volume = 18,
place = {United States},
year = {1988},
month = {4}
}