Metabolic effects of 3'-deoxyadenosine (cordycepin) and 2-halo-3'-deoxyadenosine on repair of X-ray-induced potentially lethal damage in Chinese hamster V79 cells
Journal Article
·
· Radiat. Res.; (United States)
Using cultured Chinese hamster V79 cells, an attempt has been made to examine the phosphorylation of cordycepin and its 2-halo derivatives (2-chloro-3'-deoxyadenosine, 2-bromo-3'-deoxyadenosine, and 2-iodo-3'-deoxyadenosine) by adenosine kinase, within the cells, and to correlate it with their cytotoxicities and abilities to inhibit the repair of X-ray-induced potentially lethal damage (PLDR). Of all compounds, only cordycepin was found to be phosphorylated and showed both potent cytotoxicity and ability to inhibit PLDR.
- Research Organization:
- Hokkaido Univ., Sapporo (Japan)
- OSTI ID:
- 6922833
- Journal Information:
- Radiat. Res.; (United States), Vol. 114:2
- Country of Publication:
- United States
- Language:
- English
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Inhibition of X-ray-induced potentially lethal damage (PLD) repair by cordycepin (3'-deoxyadenosine) and enhancement of its action by 2'-deoxycoformycin in Chinese Hamster hai cells in the stationary phase in Vitro
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Chinese hamster V79 cells harbor potentially lethal damage which is neither fixed nor repaired for long times after attaining maximal survival under growth conditions
Journal Article
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· Radiat. Res.; (United States)
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OSTI ID:6922833
Effect of PD 128763, a new potent inhibitor of poly(ADP-ribose) polymerase, on X-ray-induced cellular recovery processes in Chinese hamster V79 cells
Journal Article
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Sat Jun 01 00:00:00 EDT 1991
· Radiation Research; (United States)
·
OSTI ID:6922833
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Chinese hamster V79 cells harbor potentially lethal damage which is neither fixed nor repaired for long times after attaining maximal survival under growth conditions
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Wed Mar 01 00:00:00 EST 1995
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OSTI ID:6922833
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADENOSINE
PHOSPHORYLATION
RADIOSENSITIVITY EFFECTS
ANIMAL CELLS
DNA REPAIR
GENETIC RADIATION EFFECTS
CELL CULTURES
DNA
HAMSTERS
LUNGS
PHOSPHOTRANSFERASES
X RADIATION
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
CHEMICAL REACTIONS
ELECTROMAGNETIC RADIATION
ENZYMES
GENETIC EFFECTS
IONIZING RADIATIONS
MAMMALS
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANS
PHOSPHORUS-GROUP TRANSFERASES
RADIATION EFFECTS
RADIATIONS
RECOVERY
REPAIR
RESPIRATORY SYSTEM
RIBOSIDES
RODENTS
TRANSFERASES
VERTEBRATES
560120* - Radiation Effects on Biochemicals
Cells
& Tissue Culture
ADENOSINE
PHOSPHORYLATION
RADIOSENSITIVITY EFFECTS
ANIMAL CELLS
DNA REPAIR
GENETIC RADIATION EFFECTS
CELL CULTURES
DNA
HAMSTERS
LUNGS
PHOSPHOTRANSFERASES
X RADIATION
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
CHEMICAL REACTIONS
ELECTROMAGNETIC RADIATION
ENZYMES
GENETIC EFFECTS
IONIZING RADIATIONS
MAMMALS
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANS
PHOSPHORUS-GROUP TRANSFERASES
RADIATION EFFECTS
RADIATIONS
RECOVERY
REPAIR
RESPIRATORY SYSTEM
RIBOSIDES
RODENTS
TRANSFERASES
VERTEBRATES
560120* - Radiation Effects on Biochemicals
Cells
& Tissue Culture