Influence of IL-1 treatment on the reconstitution of the hemopoietic and immune systems after sublethal radiation
The influence of IL-1 administration on the recovery of the hemopoietic and immune systems from sublethal irradiation was assessed. Mice were irradiated (750 R) and injected twice daily with purified recombinant derived IL-1 beta (200 ng/injection). At various times after irradiation, the functional capacity of the hemopoietic and immune systems was determined. It was found that IL-1 therapy resulted in a significantly greater number of granulocyte-macrophage-CSF responsive colony-forming cells in the bone marrow of the irradiated mice on days 5 and 11 postirradiation but not at later times. In addition the radiation induced neutropenia recovered quicker in the IL-1-treated mice with significantly greater numbers of peripheral blood granulocytes being seen on days 15 and 20 after irradiation. The influence of IL-1 therapy on the recovery of the immune system was also assessed. Of note was the observation that mice receiving IL-1 therapy had chronically hypoplastic thymi. Although thymic cellularity increased with time after irradiation in the control mice, there was no such increase in the IL-1-treated mice. Similarly, the number of pre-B cells in the marrow of these mice was also diminished. Thus, in the IL-1-treated mice the regeneration of the peripheral immune function was retarded, characterized by a general lymphopenia and decreased splenic responses to mitogenic stimuli.
- Research Organization:
- Immunex Corporation, Seattle, WA (USA)
- OSTI ID:
- 6922627
- Journal Information:
- J. Immunol.; (United States), Vol. 140:12
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
HEMATOPOIETIC SYSTEM
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
LYMPHOKINES
RADIOSENSITIVITY EFFECTS
BONE MARROW
COLONY FORMATION
MICE
SPLEEN
SUBLETHAL IRRADIATION
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BODY
GROWTH FACTORS
IRRADIATION
MAMMALS
MITOGENS
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIATION EFFECTS
RECOVERY
RODENTS
TISSUES
VERTEBRATES
560152* - Radiation Effects on Animals- Animals