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Title: Characterization of radiation-induced emesis in the ferret

Abstract

Forty-eight ferrets (Mustela putorius furo) were individually head-shielded and radiated with bilateral /sup 60/Co gamma radiation at 100 cGy min-1 at doses ranging between 49 and 601 cGy. The emetic threshold was observed at 69 cGy, the ED50 was calculated at 77 cGy, and 100% incidence of emesis occurred at 201 cGy. With increasing doses of radiation, the latency to first emesis after radiation decreased dramatically, whereas the duration of the prodromal period increased. Two other sets of experiments suggest that dopaminergic mechanisms play a minor role in radiation-induced emesis in the ferret. Twenty-two animals were injected either intravenously or subcutaneously with 30 to 300 micrograms/kg of apomorphine. Fewer than 50% of the animals vomited to 300 micrograms/kg apomorphine; central dopaminergic receptor activation was apparent at all doses. Another eight animals received 1 mg/kg domperidone prior to either 201 (n = 4) or 401 (n = 4) cGy radiation and their emetic responses were compared with NaCl-injected-irradiated controls (n = 8). At 201 cGy, domperidone significantly reduced only the total time in emetic behavior. At 401 cGy, domperidone had no salutary effect on radiation-induced emesis. The emetic responses of the ferret to radiation and apomorphine are compared with these responsesmore » in other vomiting species.« less

Authors:
Publication Date:
Research Org.:
Armed Forces Radiobiology Research Institute, Bethesda, MD (USA)
OSTI Identifier:
6922585
Alternate Identifier(s):
OSTI ID: 6922585
Resource Type:
Journal Article
Journal Name:
Radiat. Res.; (United States)
Additional Journal Information:
Journal Volume: 114:3
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; DOPAMINE; BIOLOGICAL FUNCTIONS; RADIOSENSITIVITY EFFECTS; MAMMALS; BIOLOGICAL RADIATION EFFECTS; VOMITING; RADIOINDUCTION; COBALT 60; GAMMA RADIATION; RADIATION DOSES; RECEPTORS; AMINES; ANIMALS; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENTS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; CARDIOTONICS; CARDIOVASCULAR AGENTS; COBALT ISOTOPES; DOSES; DRUGS; ELECTROMAGNETIC RADIATION; FUNCTIONS; HYDROXY COMPOUNDS; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IONIZING RADIATIONS; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MEMBRANE PROTEINS; MINUTES LIVING RADIOISOTOPES; NEUROREGULATORS; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; PHENOLS; POLYPHENOLS; PROTEINS; RADIATION EFFECTS; RADIATIONS; RADIOISOTOPES; SYMPATHOMIMETICS; SYMPTOMS; VERTEBRATES; YEARS LIVING RADIOISOTOPES 560152* -- Radiation Effects on Animals-- Animals

Citation Formats

King, G.L. Characterization of radiation-induced emesis in the ferret. United States: N. p., 1988. Web. doi:10.2307/3577130.
King, G.L. Characterization of radiation-induced emesis in the ferret. United States. doi:10.2307/3577130.
King, G.L. Wed . "Characterization of radiation-induced emesis in the ferret". United States. doi:10.2307/3577130.
@article{osti_6922585,
title = {Characterization of radiation-induced emesis in the ferret},
author = {King, G.L.},
abstractNote = {Forty-eight ferrets (Mustela putorius furo) were individually head-shielded and radiated with bilateral /sup 60/Co gamma radiation at 100 cGy min-1 at doses ranging between 49 and 601 cGy. The emetic threshold was observed at 69 cGy, the ED50 was calculated at 77 cGy, and 100% incidence of emesis occurred at 201 cGy. With increasing doses of radiation, the latency to first emesis after radiation decreased dramatically, whereas the duration of the prodromal period increased. Two other sets of experiments suggest that dopaminergic mechanisms play a minor role in radiation-induced emesis in the ferret. Twenty-two animals were injected either intravenously or subcutaneously with 30 to 300 micrograms/kg of apomorphine. Fewer than 50% of the animals vomited to 300 micrograms/kg apomorphine; central dopaminergic receptor activation was apparent at all doses. Another eight animals received 1 mg/kg domperidone prior to either 201 (n = 4) or 401 (n = 4) cGy radiation and their emetic responses were compared with NaCl-injected-irradiated controls (n = 8). At 201 cGy, domperidone significantly reduced only the total time in emetic behavior. At 401 cGy, domperidone had no salutary effect on radiation-induced emesis. The emetic responses of the ferret to radiation and apomorphine are compared with these responses in other vomiting species.},
doi = {10.2307/3577130},
journal = {Radiat. Res.; (United States)},
number = ,
volume = 114:3,
place = {United States},
year = {1988},
month = {6}
}