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Title: Toxicity of mycotoxins for the rat pulmonary macrophage in vitro

Abstract

The presence of mycotoxins in grains is well documented. Workers in grain handling occupations are commonly exposed to grain dust aerosols. Work in our laboratory has shown that T-2 toxin is highly toxic to rat alveolar macrophages in vitro, causing loss of viability, release of radiolabeled chromium, inhibition of macromolecular synthesis, inhibition of phagocytosis, and inhibition of macrophage activation. Similarly, patulin caused a significant release of radiolabeled chromium, decrease in ATP levels, significant inhibition of protein and RNA synthesis, and inhibition of phagocytosis. The data show that both T-2 toxin and patulin are highly toxic to rat alveolar macrophages in vitro. The data further suggest that the presence of these mycotoxins in airborne respirable dust might present a hazard to exposed workers.

Authors:
; ; ;
Publication Date:
Research Org.:
National Institute for Occupational Safety and Health, Morgantown, WV
OSTI Identifier:
6915826
Alternate Identifier(s):
OSTI ID: 6915826
Resource Type:
Journal Article
Journal Name:
Environ. Health Perspect.; (United States)
Additional Journal Information:
Journal Volume: 66
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; MACROPHAGES; RADIOASSAY; TOXINS; BIOLOGICAL EFFECTS; CEREALS; CHROMIUM 51; FUNGI; IN VITRO; LUNGS; PERSONNEL; RATS; SEEDS; ANIMAL CELLS; ANIMALS; ANTIGENS; BETA DECAY RADIOISOTOPES; BODY; CHROMIUM ISOTOPES; CONNECTIVE TISSUE CELLS; ELECTRON CAPTURE RADIOISOTOPES; EVEN-ODD NUCLEI; GRASS; INTERMEDIATE MASS NUCLEI; ISOTOPES; MAMMALS; MATERIALS; NUCLEI; ORGANS; PHAGOCYTES; PLANTS; RADIOISOTOPES; RESPIRATORY SYSTEM; RODENTS; SOMATIC CELLS; TOXIC MATERIALS; VERTEBRATES 550601* -- Medicine-- Unsealed Radionuclides in Diagnostics; 560300 -- Chemicals Metabolism & Toxicology

Citation Formats

Sorenson, W.G., Gerberick, G.F., Lewis, D.M., and Castranova, V. Toxicity of mycotoxins for the rat pulmonary macrophage in vitro. United States: N. p., 1986. Web. doi:10.1289/ehp.866645.
Sorenson, W.G., Gerberick, G.F., Lewis, D.M., & Castranova, V. Toxicity of mycotoxins for the rat pulmonary macrophage in vitro. United States. doi:10.1289/ehp.866645.
Sorenson, W.G., Gerberick, G.F., Lewis, D.M., and Castranova, V. Tue . "Toxicity of mycotoxins for the rat pulmonary macrophage in vitro". United States. doi:10.1289/ehp.866645.
@article{osti_6915826,
title = {Toxicity of mycotoxins for the rat pulmonary macrophage in vitro},
author = {Sorenson, W.G. and Gerberick, G.F. and Lewis, D.M. and Castranova, V.},
abstractNote = {The presence of mycotoxins in grains is well documented. Workers in grain handling occupations are commonly exposed to grain dust aerosols. Work in our laboratory has shown that T-2 toxin is highly toxic to rat alveolar macrophages in vitro, causing loss of viability, release of radiolabeled chromium, inhibition of macromolecular synthesis, inhibition of phagocytosis, and inhibition of macrophage activation. Similarly, patulin caused a significant release of radiolabeled chromium, decrease in ATP levels, significant inhibition of protein and RNA synthesis, and inhibition of phagocytosis. The data show that both T-2 toxin and patulin are highly toxic to rat alveolar macrophages in vitro. The data further suggest that the presence of these mycotoxins in airborne respirable dust might present a hazard to exposed workers.},
doi = {10.1289/ehp.866645},
journal = {Environ. Health Perspect.; (United States)},
number = ,
volume = 66,
place = {United States},
year = {1986},
month = {4}
}