Ocular penetration, toxicity, and radiosensitization effects of two hypoxic cell radiosensitizers on retinoblastoma
Two new radiosensitizing drugs, SR-2508 and SR-2555, were studied for their in vivo toxicity and absorption properties. For both drugs, 100 mg dissolved in 0.5 mL of normal saline resulted in the maximum acceptable level of toxicity when injected subconjunctivally in rabbit eyes as determined by ocular and histopathologic changes. SR-2508 showed higher ocular and systemic absorption than SR-2555. The radiosensitizing ability of these drugs was studied using Chinese hamster ovary cells and the retinoblastoma cell line, V79c6. Results of the in vitro radiation experiments indicate that both drugs are comparable with misonidazole in their radiosensitizing ability, with SR-2508 being slightly more effective than SR-2555. Because of their relative high ocular absorption and low toxicity in comparison with misonidazole, these two drugs, particularly SR-2508, may be of clinical value and could be considered for adjunctive use as radiosensitizers of hypoxic tumors such as retinoblastoma.
- Research Organization:
- Univ. of British Columbia, Vancouver
- OSTI ID:
- 6914515
- Journal Information:
- Arch. Ophthalmol. (Chicago); (United States), Vol. 11
- Country of Publication:
- United States
- Language:
- English
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RADIOSENSITIZERS
RADIOSENSITIVITY EFFECTS
TOXICITY
ANOXIA
CHO CELLS
EYES
NEOPLASMS
RABBITS
TESTING
ANIMAL CELLS
ANIMALS
BODY
BODY AREAS
DISEASES
DRUGS
FACE
HEAD
MAMMALS
ORGANS
SENSE ORGANS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals
560120 - Radiation Effects on Biochemicals
Cells
& Tissue Culture