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Title: Role of the area postrema in radiation-induced taste aversion learning and emesis in cats

Abstract

The role of the area postrema in radiation-induced emesis and taste aversion learning and the relationship between these behaviors were studied in cats. The potential involvement of neural factors which might be independent of the area postrema was minimized by using low levels of ionizing radiation (100 rads at a dose rate of 40 rads/min) to elicit a taste aversion, and by using body-only exposures (4500 and 6000 rads at 450 rads/min) to produce emesis. Lesions of the area postrema disrupted both taste aversion learning and emesis following irradiation. These results, which indicate that the area postrema is involved in the mediation of both radiation-induced emesis and taste aversion learning in cats under these experimental conditions, are interpreted as being consistent with the hypotheses that similar mechanisms mediate both responses to exposure to ionizing radiation, and that the taste aversion learning paradigm can therefore serve as a model system for studying radiation-induced emesis.

Authors:
; ; ;
Publication Date:
Research Org.:
Armed Forces Radiobiology Research Institute, Bethesda, MD
OSTI Identifier:
6914413
Alternate Identifier(s):
OSTI ID: 6914413
Resource Type:
Journal Article
Journal Name:
Physiol. Behav.; (United States)
Additional Journal Information:
Journal Volume: 5
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; TASTE BUDS; BIOLOGICAL RADIATION EFFECTS; VOMITING; RADIOINDUCTION; BEHAVIOR; CATS; LEARNING; ANIMALS; BIOLOGICAL EFFECTS; BODY; MAMMALS; ORGANS; RADIATION EFFECTS; SENSE ORGANS; SYMPTOMS; VERTEBRATES 560152* -- Radiation Effects on Animals-- Animals

Citation Formats

Rabin, B.M., Hunt, W.A., Chedester, A.L., and Lee, J. Role of the area postrema in radiation-induced taste aversion learning and emesis in cats. United States: N. p., 1986. Web. doi:10.1016/0031-9384(86)90189-7.
Rabin, B.M., Hunt, W.A., Chedester, A.L., & Lee, J. Role of the area postrema in radiation-induced taste aversion learning and emesis in cats. United States. doi:10.1016/0031-9384(86)90189-7.
Rabin, B.M., Hunt, W.A., Chedester, A.L., and Lee, J. Wed . "Role of the area postrema in radiation-induced taste aversion learning and emesis in cats". United States. doi:10.1016/0031-9384(86)90189-7.
@article{osti_6914413,
title = {Role of the area postrema in radiation-induced taste aversion learning and emesis in cats},
author = {Rabin, B.M. and Hunt, W.A. and Chedester, A.L. and Lee, J.},
abstractNote = {The role of the area postrema in radiation-induced emesis and taste aversion learning and the relationship between these behaviors were studied in cats. The potential involvement of neural factors which might be independent of the area postrema was minimized by using low levels of ionizing radiation (100 rads at a dose rate of 40 rads/min) to elicit a taste aversion, and by using body-only exposures (4500 and 6000 rads at 450 rads/min) to produce emesis. Lesions of the area postrema disrupted both taste aversion learning and emesis following irradiation. These results, which indicate that the area postrema is involved in the mediation of both radiation-induced emesis and taste aversion learning in cats under these experimental conditions, are interpreted as being consistent with the hypotheses that similar mechanisms mediate both responses to exposure to ionizing radiation, and that the taste aversion learning paradigm can therefore serve as a model system for studying radiation-induced emesis.},
doi = {10.1016/0031-9384(86)90189-7},
journal = {Physiol. Behav.; (United States)},
number = ,
volume = 5,
place = {United States},
year = {1986},
month = {1}
}