Suppression of intralysosomal proteolysis aggravates structural damage and functional impairment of liver lysosomes in rats with toxic hepatitis
Journal Article
·
· Bull. Exp. Biol. Med. (Engl. Transl.); (United States)
OSTI ID:6906863
This paper estimates the effect of lowering protein catabolism in the lysosomes on structural and functional properties of the latter during liver damage. For comparison, polyvinylpyrrolidone (PVP), which is inert relative to intralysosomal proteolysis, and which also accumulates largely in lysosomes of the kupffer cells of the liver, was used. The uptake of labeled bovine serum albuman (C 14-BSA) by the liver is shown and the rate of intralysosomal proteolysis is given 24 hours after administration of suramin an CCl/sub 4/ to rats. It is suggested that it is risky to use drugs which inhibit intralysosomal proteolysis in the treatment of patients with acute hepatitis.
- Research Organization:
- Ministry of Health of the RSFSR
- OSTI ID:
- 6906863
- Journal Information:
- Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Vol. 100:8
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
ALBUMINS
CATABOLISM
CARBON TETRACHLORIDE
BIOLOGICAL EFFECTS
LYSOSOMES
PROTEOLYSIS
RATS
HEPATITIS
BIOLOGICAL ACCUMULATION
BIOLOGICAL FUNCTIONS
CARBON 14 COMPOUNDS
DAMAGE
ENZYME ACTIVITY
LIVER CELLS
PVP
RETENTION
TRACER TECHNIQUES
UPTAKE
AMIDES
ANIMAL CELLS
ANIMALS
AZOLES
BLOOD SUBSTITUTES
CELL CONSTITUENTS
CHEMICAL REACTIONS
CHLORINATED ALIPHATIC HYDROCARBONS
DECOMPOSITION
DIGESTIVE SYSTEM DISEASES
DISEASES
DRUGS
FUNCTIONS
HALOGENATED ALIPHATIC HYDROCARBONS
HEMATOLOGIC AGENTS
HETEROCYCLIC COMPOUNDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LACTAMS
MAMMALS
METABOLISM
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC POLYMERS
ORGANOIDS
POLYMERS
POLYVINYLS
PROTEINS
PYRROLES
PYRROLIDONES
RODENTS
SOMATIC CELLS
VERTEBRATES
550301* - Cytology- Tracer Techniques
550501 - Metabolism- Tracer Techniques
ALBUMINS
CATABOLISM
CARBON TETRACHLORIDE
BIOLOGICAL EFFECTS
LYSOSOMES
PROTEOLYSIS
RATS
HEPATITIS
BIOLOGICAL ACCUMULATION
BIOLOGICAL FUNCTIONS
CARBON 14 COMPOUNDS
DAMAGE
ENZYME ACTIVITY
LIVER CELLS
PVP
RETENTION
TRACER TECHNIQUES
UPTAKE
AMIDES
ANIMAL CELLS
ANIMALS
AZOLES
BLOOD SUBSTITUTES
CELL CONSTITUENTS
CHEMICAL REACTIONS
CHLORINATED ALIPHATIC HYDROCARBONS
DECOMPOSITION
DIGESTIVE SYSTEM DISEASES
DISEASES
DRUGS
FUNCTIONS
HALOGENATED ALIPHATIC HYDROCARBONS
HEMATOLOGIC AGENTS
HETEROCYCLIC COMPOUNDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LACTAMS
MAMMALS
METABOLISM
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC POLYMERS
ORGANOIDS
POLYMERS
POLYVINYLS
PROTEINS
PYRROLES
PYRROLIDONES
RODENTS
SOMATIC CELLS
VERTEBRATES
550301* - Cytology- Tracer Techniques
550501 - Metabolism- Tracer Techniques