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Title: Responses to sulfur dioxide and exercise by medication-depend asthmatics: Effect of varying medication levels

Abstract

Twenty-one volunteers with moderate to severe asthma were exposed to sulfur dioxide (SO{sub 2}) at concentrations of O (control), 0.3, and 0.6 ppm in each of three medication states: (1) low (much of their usual asthma medication withheld), (2) normal (each subject on his own usual medication schedule), and (3) high (usual medication supplemented by inhaled metaproterenol before exposure). Theophylline, the medication usually taken by subjects, was often supplemented by beta-adrenergics. Exposures were for 10 min and were accompanied by continuous heavy exercise (ventilation {approximately} 50 1/min). Lung function and symptoms were measured before and after exposure. With normal medication, symptomatic bronchoconstriction occurred with exercise and was exacerbated by 0.6 ppm SO{sub 2}, as reported for mildly unmedicated asthmatics studied previously. Both baseline and post-exposure lung function were noticeably worse in the low-medication state. High medication improved baseline lung function and prevented most broncho-constrictive effect of SO{sup 2}/exercise. High medication also increased heart rate and apparently induced tremor or nervousness in some individuals.

Authors:
; ; ; ; ;  [1]
  1. (Univ. of. Southern California, Downey (USA))
OSTI Identifier:
6905258
Alternate Identifier(s):
OSTI ID: 6905258
Resource Type:
Journal Article
Resource Relation:
Journal Name: Archives of Environmental Health; (USA); Journal Volume: 45:1
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; EXERCISE; BIOLOGICAL EFFECTS; SULFUR DIOXIDE; HEALTH HAZARDS; ASTHMA; BIOLOGICAL FUNCTIONS; DRUGS; LUNGS; BODY; CHALCOGENIDES; DISEASES; FUNCTIONS; HAZARDS; ORGANS; OXIDES; OXYGEN COMPOUNDS; RESPIRATORY SYSTEM; RESPIRATORY SYSTEM DISEASES; SULFUR COMPOUNDS; SULFUR OXIDES 560300* -- Chemicals Metabolism & Toxicology

Citation Formats

Linn, W.S., Shamoo, D.A., Peng, R.C., Clark, K.W., Avol, E.L., and Hackney, J.D. Responses to sulfur dioxide and exercise by medication-depend asthmatics: Effect of varying medication levels. United States: N. p., Web.
Linn, W.S., Shamoo, D.A., Peng, R.C., Clark, K.W., Avol, E.L., & Hackney, J.D. Responses to sulfur dioxide and exercise by medication-depend asthmatics: Effect of varying medication levels. United States.
Linn, W.S., Shamoo, D.A., Peng, R.C., Clark, K.W., Avol, E.L., and Hackney, J.D. . "Responses to sulfur dioxide and exercise by medication-depend asthmatics: Effect of varying medication levels". United States.
@article{osti_6905258,
title = {Responses to sulfur dioxide and exercise by medication-depend asthmatics: Effect of varying medication levels},
author = {Linn, W.S. and Shamoo, D.A. and Peng, R.C. and Clark, K.W. and Avol, E.L. and Hackney, J.D.},
abstractNote = {Twenty-one volunteers with moderate to severe asthma were exposed to sulfur dioxide (SO{sub 2}) at concentrations of O (control), 0.3, and 0.6 ppm in each of three medication states: (1) low (much of their usual asthma medication withheld), (2) normal (each subject on his own usual medication schedule), and (3) high (usual medication supplemented by inhaled metaproterenol before exposure). Theophylline, the medication usually taken by subjects, was often supplemented by beta-adrenergics. Exposures were for 10 min and were accompanied by continuous heavy exercise (ventilation {approximately} 50 1/min). Lung function and symptoms were measured before and after exposure. With normal medication, symptomatic bronchoconstriction occurred with exercise and was exacerbated by 0.6 ppm SO{sub 2}, as reported for mildly unmedicated asthmatics studied previously. Both baseline and post-exposure lung function were noticeably worse in the low-medication state. High medication improved baseline lung function and prevented most broncho-constrictive effect of SO{sup 2}/exercise. High medication also increased heart rate and apparently induced tremor or nervousness in some individuals.},
doi = {},
journal = {Archives of Environmental Health; (USA)},
number = ,
volume = 45:1,
place = {United States},
year = {},
month = {}
}