Human genes encoding the voltage-dependent anion channel (VDAC) of the outer mitochondrial membrane: Mapping and identification of two new isoforms
- Oregon Health Sciences Univ., Portland, OR (United States)
- Baylor College of Medicine, Houston, TX (United States)
The voltage-dependent anion channel of the mitochondrial outer membrane (VDAC) is a small, abundant pore-forming protein found in the outer membranes of all eukaryotic mitochondria. The VDAC protein is believed to form the major pathway for movement of adenine nucleotides through the outer membrane and to be the mitochondrial binding site for hexokinase and glycerol kinase. Previous studies have indicated that at least two human VDAC isoforms are expressed. Here, the authors report the mapping of VDAC1 to the X chromosome in the interval Xq13-q21 and VDAC2 to chromosome 21 by polymerase chain reaction and restriction analysis of a human/rodent somatic cell mapping panel. In the process of mapping these genes, they identified and mapped two additional sequences highly homologous to VDAC1. VDAC3 maps to chromosome 12 and VDAC4 maps to chromosome 1. The locations of VDAC1 and VDAC4 have been confirmed by fluorescence in situ hybridization analysis. Future studies will be aimed at defining the specific physiological role of each member of this family of channel proteins. 15 refs., 3 figs., 1 tab.
- OSTI ID:
- 6904074
- Journal Information:
- Genomics; (United States), Vol. 20:1; ISSN 0888-7543
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
HUMAN CHROMOSOME 1
GENETIC MAPPING
HUMAN CHROMOSOME 12
HUMAN CHROMOSOME 21
HUMAN X CHROMOSOME
PORINS
GENES
DNA HYBRIDIZATION
CHROMOSOMES
HETEROCHROMOSOMES
HUMAN CHROMOSOMES
HYBRIDIZATION
MAPPING
MEMBRANE PROTEINS
ORGANIC COMPOUNDS
PROTEINS
X CHROMOSOME
550400* - Genetics