Transfer coefficients for L-valine and the rate of incorporation of L-(1-/sup 14/C) valine into proteins in normal adult rat brain

Journal Article · Mon Aug 01 00:00:00 EDT 1988 · J. Cereb. Blood Flow Metab.; (United States)

DOI:https://doi.org/10.1038/jcbfm.1988.101· OSTI ID:6902025

Kirikae, M; Diksic, M; Yamamoto, Y L

An autoradiographic method for the measurement of the rate of valine incorporation into brain proteins is described. The transfer coefficients for valine into and out of the brain and the rate of valine incorporation into normal rat brain proteins are given. The valine incorporation and the transfer constants of valine between different biological compartments are provided for 14 gray matter and 2 white matter structures of an adult rat brain. The rate of valine incorporation varies between 0.52 +/- 0.19 nmol/g/min in white matter and 1.94 +/- 0.47 in inferior colliculus (gray matter). Generally, the rate of valine incorporation is about three to four times higher in the gray matter than in the white matter structures.

• Research Organization: Montreal Neurological Institute (Canada)
• OSTI ID: 6902025
• Journal Information: J. Cereb. Blood Flow Metab.; (United States), Vol. 8:4
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
PROTEINS
BIOSYNTHESIS
VALINE
METABOLISM
AUTORADIOGRAPHY
BRAIN
CARBON 14 COMPOUNDS
RATS
TISSUE DISTRIBUTION
AMINO ACIDS
ANIMALS
BODY
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
DISTRIBUTION
LABELLED COMPOUNDS
MAMMALS
NERVOUS SYSTEM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RODENTS
SYNTHESIS
VERTEBRATES
550501* - Metabolism- Tracer Techniques