Effect of dietary fat on x-ray-induced mammary cancer in Sprague-Dawley rats

Journal Article · Sat Mar 01 00:00:00 EST 1980 · J. Natl. Cancer Inst.; (United States)

OSTI ID:6880241

Silverman, J ^[1]; Shellabarger, C J; Holtzman, S; Stone, J P; Weisburger, J H

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1. Naylor Dana Inst. for Disease Prevention, Valhalla, NY

We studied the effect of dietary fat levels on the induction of mammary cancer by 350 rads total-body x-radiation given to noninbred albino Sprague-Dawley rats at 50 days of age. Compared to rats on a low-fat (LF) diet (5% lard), rats on a high-fat (HF) diet (20% lard) from 30 days of age had more tumors, with a higher multiplicity of carcinomas per rat. LF-fed groups exhibited a longer median tumor latency period than did HF-fed groups. A similar trend toward more tumors with an earlier time of death was seen in rats given single iv doses of 50 mg 1-methyl-1-nitrosourea/kg and fed an HF diet as compared to an LF diet.

• OSTI ID: 6880241
• Journal Information: J. Natl. Cancer Inst.; (United States), Vol. 64:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CARCINOGENESIS
RADIOINDUCTION
FATS
COMPARATIVE EVALUATIONS
MAMMARY GLANDS
DELAYED RADIATION EFFECTS
RESPONSE MODIFYING FACTORS
DIET
X RADIATION
SIDE EFFECTS
INTRAVENOUS INJECTION
LATENCY PERIOD
NEOPLASMS
NITROSO COMPOUNDS
RATS
WHOLE-BODY IRRADIATION
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DISEASES
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
GLANDS
INJECTION
INTAKE
IONIZING RADIATIONS
IRRADIATION
MAMMALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOGENESIS
RADIATION EFFECTS
RADIATIONS
RODENTS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals