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Title: Bolus injections of measured amounts of radioactivity

Abstract

Many time-based radionuclide techniques, such as glomerular filtration rate measurement (GFR), require prompt intravenous delivery of and accurately measured tracer bolus with minimal residual tracer retention at the injection site. The quality assurance aspects of two antecubital vein, quantitative injection techniques were investigated. A flush bolus technique using a tuberculin syringe piggybacked onto a 10-ml saline flush was compared to a single blood pressure cuff injection technique. Scintillation camera data for each technique were compared for bolus duration in the abdominal aorta and for residual activity at the injection site at 5 min. Bolus times were measured as the FWHM of the gamma variate fit to the abdominal aortic regional time-activity curves. Relatively little focal activity was seen in the antecubital injection site following the flush bolus: marked residual activity was seen following the blood pressure cuff injections. The injection site/arm background ratios averaged 1.3 for the flush bolus and 30.1 for the cuff technique. Although both methods allowed accurate in vitro determination of administered radioactivity, only the tuberculin syringe flush bolus technique was acceptable for time-based quantitation because of its superior in vivo characteristics.

Authors:
; ; ;
Publication Date:
Research Org.:
Univ. of Western Ontario, London (Canada)
OSTI Identifier:
6879158
Resource Type:
Journal Article
Resource Relation:
Journal Name: J. Nucl. Med. Technol.; (United States); Journal Volume: 16:1
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; KIDNEYS; DYNAMIC FUNCTION STUDIES; SCINTISCANNING; RADIOPHARMACEUTICALS; RENAL CLEARANCE; DIAGNOSTIC USES; GLOMERULI; PATIENTS; ULTRAFILTRATION; BODY; CLEARANCE; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DRUGS; EXCRETION; FILTRATION; LABELLED COMPOUNDS; ORGANS; RADIOISOTOPE SCANNING; SEPARATION PROCESSES; USES 550601* -- Medicine-- Unsealed Radionuclides in Diagnostics

Citation Formats

Wesolowski, C.A., Hogendoorn, P., Vandierendonck, R., and Driedger, A.A.. Bolus injections of measured amounts of radioactivity. United States: N. p., 1988. Web.
Wesolowski, C.A., Hogendoorn, P., Vandierendonck, R., & Driedger, A.A.. Bolus injections of measured amounts of radioactivity. United States.
Wesolowski, C.A., Hogendoorn, P., Vandierendonck, R., and Driedger, A.A.. 1988. "Bolus injections of measured amounts of radioactivity". United States. doi:.
@article{osti_6879158,
title = {Bolus injections of measured amounts of radioactivity},
author = {Wesolowski, C.A. and Hogendoorn, P. and Vandierendonck, R. and Driedger, A.A.},
abstractNote = {Many time-based radionuclide techniques, such as glomerular filtration rate measurement (GFR), require prompt intravenous delivery of and accurately measured tracer bolus with minimal residual tracer retention at the injection site. The quality assurance aspects of two antecubital vein, quantitative injection techniques were investigated. A flush bolus technique using a tuberculin syringe piggybacked onto a 10-ml saline flush was compared to a single blood pressure cuff injection technique. Scintillation camera data for each technique were compared for bolus duration in the abdominal aorta and for residual activity at the injection site at 5 min. Bolus times were measured as the FWHM of the gamma variate fit to the abdominal aortic regional time-activity curves. Relatively little focal activity was seen in the antecubital injection site following the flush bolus: marked residual activity was seen following the blood pressure cuff injections. The injection site/arm background ratios averaged 1.3 for the flush bolus and 30.1 for the cuff technique. Although both methods allowed accurate in vitro determination of administered radioactivity, only the tuberculin syringe flush bolus technique was acceptable for time-based quantitation because of its superior in vivo characteristics.},
doi = {},
journal = {J. Nucl. Med. Technol.; (United States)},
number = ,
volume = 16:1,
place = {United States},
year = 1988,
month = 3
}
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