Multifractionation of /sup 60/Co gamma-rays reduces neoplastic transformation in vitro

Journal Article · Wed Feb 01 00:00:00 EST 1984 · Carcinogenesis (N.Y.); (United States)

DOI:https://doi.org/10.1093/carcin/5.2.193· OSTI ID:6879028

Hill, C K ^[1]; Han, A ^[1]; Buonaguro, F ^[2]; Elkind, M M ^[1]

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1. Argonne National Lab., IL (USA)
2. Naples Univ. (Italy). Ist. di Patologia Generale

Incidences of neoplastic transformation of 10T1/2 cells, derived from a C3H mouse embryo, were measured following irradiation of cells with /sup 60/Co ..gamma..-rays delivered in single total doses, from 25 to 300 rads, or in different numbers of fractions, and with different time intervals between fractions. Throughout the range of total doses that was examined (25 - 300 rads) exposure of asynchronous, actively growing 10T1/2 cells to a dose of ..gamma..-rays in five equal daily fractions, rather than in a single exposure, results in a significant reduction in transformation frequency. The initial part of the induction curve fits a straight line quite well. The slope of the line for five daily fractions is approx. 3-fold less steep than that for single exposures. A further increase in the interfraction interval, to 48 h, or further reductions in the dose per fraction, led to additional decreases in the incidence of neoplastic transformation. These observations are consistent with a net 'error-free' repair of subtransformation damage as a result of protracted irradiation with /sup 60/Co ..gamma..-rays.

• OSTI ID: 6879028
• Journal Information: Carcinogenesis (N.Y.); (United States), Vol. 5:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CELL CULTURES
ONCOGENIC TRANSFORMATIONS
RADIOINDUCTION
CARCINOGENESIS
COBALT 60
DOSE-RESPONSE RELATIONSHIPS
EMBRYONIC CELLS
FRACTIONATED IRRADIATION
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MICE
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
COBALT ISOTOPES
ELECTROMAGNETIC RADIATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
PATHOGENESIS
RADIATIONS
RADIOISOTOPES
RODENTS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560121* - Radiation Effects on Cells- External Source- (-1987)