skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Anesthesia cutoff phenomenon: Interfacial hydrogen bonding

Abstract

Anesthesia cutoff refers to the phenomenon of loss of anesthetic potency in a homologous series of alkanes and their derivatives when their sizes become too large. In this study, hydrogen bonding of 1-alkanol series (ethanol to eicosanol) to dipalmitoyl-L-alpha-phosphatidylcholine (DPPC) was studied by Fourier transform infrared spectroscopy (FTIR) in DPPC-D2O-in-CCl4 reversed micelles. The alkanols formed hydrogen bonds with the phosphate moiety of DPPC and released the DPPC-bound deuterated water, evidenced by increases in the bound O-H stretching signal of the alkanol-DPPC complex and also in the free O-D stretching band of unbound D2O. These effects increased according to the elongation of the carbon chain of 1-alkanols from ethanol (C2) to 1-decanol (C10), but suddenly almost disappeared at 1-tetradecanol (C14). Anesthetic potencies of these alkanols, estimated by the activity of brine shrimps, were linearly related to hydrogen bond-breaking activities below C10 and agreed with the FTIR data in the cutoff at C10.

Authors:
; ; ;  [1]
  1. (Univ. of Utah School of Medicine, Salt Lake City (USA))
Publication Date:
OSTI Identifier:
6871594
Resource Type:
Journal Article
Resource Relation:
Journal Name: Science (Washington, D.C.); (USA); Journal Volume: 248:4955
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; ANESTHESIA; STRUCTURE-ACTIVITY RELATIONSHIPS; HYDROGEN; CHEMICAL BONDS; BIOLOGICAL MODELS; DEUTERIUM; HEAVY WATER; LIPOSOMES; SHRIMP; THERMODYNAMICS; TRACER TECHNIQUES; ANIMALS; AQUATIC ORGANISMS; ARTHROPODS; CELL CONSTITUENTS; CRUSTACEANS; DECAPODS; ELEMENTS; HYDROGEN COMPOUNDS; HYDROGEN ISOTOPES; INVERTEBRATES; ISOTOPE APPLICATIONS; ISOTOPES; LIGHT NUCLEI; NONMETALS; NUCLEI; ODD-ODD NUCLEI; ORGANOIDS; OXYGEN COMPOUNDS; STABLE ISOTOPES; WATER 550201* -- Biochemistry-- Tracer Techniques

Citation Formats

Chiou, J.S., Ma, S.M., Kamaya, H., and Ueda, I.. Anesthesia cutoff phenomenon: Interfacial hydrogen bonding. United States: N. p., 1990. Web. doi:10.1126/science.2159183.
Chiou, J.S., Ma, S.M., Kamaya, H., & Ueda, I.. Anesthesia cutoff phenomenon: Interfacial hydrogen bonding. United States. doi:10.1126/science.2159183.
Chiou, J.S., Ma, S.M., Kamaya, H., and Ueda, I.. 1990. "Anesthesia cutoff phenomenon: Interfacial hydrogen bonding". United States. doi:10.1126/science.2159183.
@article{osti_6871594,
title = {Anesthesia cutoff phenomenon: Interfacial hydrogen bonding},
author = {Chiou, J.S. and Ma, S.M. and Kamaya, H. and Ueda, I.},
abstractNote = {Anesthesia cutoff refers to the phenomenon of loss of anesthetic potency in a homologous series of alkanes and their derivatives when their sizes become too large. In this study, hydrogen bonding of 1-alkanol series (ethanol to eicosanol) to dipalmitoyl-L-alpha-phosphatidylcholine (DPPC) was studied by Fourier transform infrared spectroscopy (FTIR) in DPPC-D2O-in-CCl4 reversed micelles. The alkanols formed hydrogen bonds with the phosphate moiety of DPPC and released the DPPC-bound deuterated water, evidenced by increases in the bound O-H stretching signal of the alkanol-DPPC complex and also in the free O-D stretching band of unbound D2O. These effects increased according to the elongation of the carbon chain of 1-alkanols from ethanol (C2) to 1-decanol (C10), but suddenly almost disappeared at 1-tetradecanol (C14). Anesthetic potencies of these alkanols, estimated by the activity of brine shrimps, were linearly related to hydrogen bond-breaking activities below C10 and agreed with the FTIR data in the cutoff at C10.},
doi = {10.1126/science.2159183},
journal = {Science (Washington, D.C.); (USA)},
number = ,
volume = 248:4955,
place = {United States},
year = 1990,
month = 5
}
  • CaF{sub 2} films are deposited on hydrogen-terminated diamond (H-diamond) by a radio-frequency sputter-deposition technique at room temperature. Interfacial chemical bonding state and band alignment of CaF{sub 2}/H-diamond heterojunction are investigated by X-ray photoelectron spectroscopy. It is confirmed that there are only C-Ca bonds at the CaF{sub 2}/H-diamond heterointerface. Valence and conductance band offsets of the CaF{sub 2}/H-diamond heterojunciton are determined to be 3.7 {+-} 0.2 and 0.3 {+-} 0.2 eV, respectively. It shows a type I straddling band configuration. The large valence band offset suggests advantage of the CaF{sub 2}/H-diamond heterojunciton for the development of high power and high frequencymore » field effect transistors.« less
  • It has been shown that the minimum achievable spherical critical masses for the three main fissile isotopes of /sup 235/U, /sup 239/Pu, and /sup 233/U at normal temperature and density with BeH/sub 2/ as moderator and with a thick /sup 9/Be reflector is lower than for any other system reported so far. In this context the feasibility of decreasing the critical masses further by exploiting the Bragg cutoff phenomenon in cooled beryllium reflectors was investigated. The reactivity gain obtainable in cooling part (or whole) of the beryllium reflector of a BeH/sub 2/moderated homogeneous /sup 233/U system to liquid nitrogen temperaturemore » (78 K) is explored. Transport theory calculations show that a 50-cm two-zone beryllium reflector with a cooled inner zone of optimum thickness ( about15 cm) at 78 K has an improved albedo and results in a further reduction of 6 to 8% in the critical mass.« less
  • The influence of interfacial shear strength superconducting Y-Ba-Cu-O and silver and that between Bi-Pb-Sr-Ca-Cu-O and silver on the multiple fracture of the oxides embedded in silver-sheathed composite wires, prepared by a powder-in-tube method, on the multiple fracture of the oxides was analyzed. The stress distribution in the oxide was calculated based on the proposed method, and the multiple-fracture phenomenon was simulated by means of a Monte Carlo simulation method. From the comparison of the experimental results with those obtained by the simulation, the interfacial shear strength between Y-Ba-Cu-O and silver and that between Bi-Pb-Sr-Ca-Cu-O and silver were estimated to bemore » nearly 30 and 40 MPa, respectively.« less