Cardiorespiratory response to cyanide of arterial chemoreceptors in fetal lambs

Journal Article · Fri May 01 00:00:00 EDT 1987 · Am. J. Physiol.; (United States)

OSTI ID:6861012

Itskovitz, J; Rudolph, A M

Cardiorespiratory response to the stimulation of the carotid and aortic receptors by sodium cyanide was examined in fetal lambs in utero at 0.8 (120 days) gestation. Injections of 50-400 ..mu..g cyanide into the inferior vena cava or the carotid artery of intact fetuses elicited bradycardia and respiratory responses that varied from a single gasp to rhythmic respiratory movements but no significant change in arterial blood pressure. Carotid sinus denervation eliminated the cardiorespiratory response to intracarotid injection of cyanide and sinoaortic denervation abolished the response to inferior vena caval injection. It is concluded that in fetal lamb in utero the aortic and carotid bodies are active, and hypoxic stimulation of these chemoreceptors results in cardiorespiratory response characterized by slowing of fetal heart rate, respiratory effort, and no consistent change in arterial blood pressure.

• Research Organization: Univ. of California, San Francisco (USA)
• OSTI ID: 6861012
• Journal Information: Am. J. Physiol.; (United States), Vol. 252:5
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CYANIDES
BIOLOGICAL EFFECTS
PRENATAL EXPOSURE
RESPIRATION
PHYSIOLOGY
ANOXIA
BLOOD PRESSURE
CARDIOVASCULAR SYSTEM
FETUSES
PREGNANCY
RECEPTORS
RESPIRATORY SYSTEM
SHEEP
SODIUM COMPOUNDS
ALKALI METAL COMPOUNDS
ANIMALS
DOMESTIC ANIMALS
MAMMALS
MEMBRANE PROTEINS
ORGANIC COMPOUNDS
PROTEINS
RUMINANTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology