Autoregulation of nephron filtration rate in the dog assessed by indicator-dilution technique. [Iodine isotopes]

Journal Article · Sat Oct 01 00:00:00 EDT 1977 · Am. J. Physiol.; (United States)

OSTI ID:6859156

Williams, R H; Thomas, C; Bell, D; Nevar, L F

Micropuncture studies were conducted in anesthetized dogs to evaluate single nephron glomerular filtrate rate (SNGFR) and SNGFR autoregulation when assessed by means of an indicator-dilution technique (SNGFRID), which does not require interruption of distal volume delivery. In 18 dogs, control renal arterial pressure was 124 +/- 11 mm Hg (SD), renal blood flow (RBF) was 185 +/- 58 ml/min, and whole kidney GRF was 37 +/- 7 ml/min. In 10 animals, renal arterial pressure was reduced to an average of 94 +/- 8 mm Hg; whole kidney autoregulation was highly efficient and average RBF and GRF remained within 1 and 3% of their control values. Likewise, SNGFRID was not significantly altered at 52 +/- 17 and 52 +/- 16 nl/min. In contrast, SNGFRTC decreased significantly from 72 +/- 17 to 51 +/- 13 ml/min. These results indicate that the indicator-dilution technique provides a reliable assessment of SNGFR and allows the manifestation of single nephron autoregulatory behavior. They provide further support for the hypothesis that maintenance of distal volume delivery may be a necessary aspect of the autoregulation phenomenon.

• Research Organization: Univ. of Alabama, Birmingham
• OSTI ID: 6859156
• Journal Information: Am. J. Physiol.; (United States), Vol. 233:4
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
GLOMERULI
FILTRATION
IODINE ISOTOPES
ISOTOPE DILUTION
KIDNEYS
BLOOD PRESSURE
HOMEOSTASIS
CONTROL
DOGS
MEASURING METHODS
ANIMALS
BODY
ISOTOPE APPLICATIONS
MAMMALS
ORGANS
SEPARATION PROCESSES
TRACER TECHNIQUES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
551000 - Physiological Systems