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Title: A new method for determining dose rate distribution from radioimmuno-therapy using radiochromic media

Abstract

The purpose of this study is to describe and evaluate a new, simple, inexpensive method for directly measuring the radiation dose and its spatial distribution generated from explanted tissues of animals previously injected with radiolabeled immunoconjugates or other agents. This technique uses the newly developed radiochromic dye medium (Gafchromic[trademark]) which responds reproducibly for therapeutic dose exposures, has high spatial resolution, does not require film processing, and is relatively insensitive to ambient light. The authors have evaluated the dose distribution from LS174T tumors and selected normal tissues in nude mice previously injected with [sup 90]Y labeled anti-carcinoembryonic antigen antibodies. Individual tissues from sacrificed animals are halved and the flat section of the tissue is placed onto the dosimetry media and then frozen. The dosimetry medium is exposed to beta and Bremsstrahlung radiation originating from the frozen tissues. The relative darkening of the dosimetry medium depends on the dose deposited in the film. The dosimetry medium is scanned with a commercial flatbed scanner and the image intensity is digitally stored and quantitatively analyzed. Isodose curves are generated and compared to the actual tissue outline. The absorbed dose distribution due to [sup 90]Y exposure show only slight gradients in the interior of themore » tissue, with a markedly decreasing dose near the edges of the tissue. In addition, the isodose curves follow the tissue outline except in regions having radii of curvature smaller than the range of the beta-particle (R90 = 5 mm). These results suggest that the shape of the tumor, and its curvature, are important in determining the minimum dose delivered to the tumor by radiation from [sup 90]Y monoclonal antibodies, and hence in evaluating the tumor response to the radiation. 28 refs., 8 figs.« less

Authors:
; ; ; ; ;  [1];  [2]
  1. (Johns Hopkins Hospital, Baltimore, MD (United States))
  2. (Hybritech Inc., San Diego, CA (United States))
Publication Date:
OSTI Identifier:
6858696
Alternate Identifier(s):
OSTI ID: 6858696
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; (United States); Journal Volume: 28:2
Country of Publication:
United States
Language:
English
Subject:
61 RADIATION PROTECTION AND DOSIMETRY; RADIOPHARMACEUTICALS; SPATIAL DOSE DISTRIBUTIONS; YTTRIUM 90; RADIOIMMUNOTHERAPY; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; DAYS LIVING RADIOISOTOPES; DRUGS; HOURS LIVING RADIOISOTOPES; IMMUNOTHERAPY; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MEDICINE; NUCLEAR MEDICINE; NUCLEI; ODD-ODD NUCLEI; RADIATION DOSE DISTRIBUTIONS; RADIOISOTOPES; RADIOLOGY; RADIOTHERAPY; THERAPY; YTTRIUM ISOTOPES 560101* -- Biomedical Sciences, Applied Studies-- Radiation Effects-- Dosimetry & Monitoring-- (1992-)

Citation Formats

Mayer, R., Dillehay, L.E., Shao, Y., Song, S., Zhang, Y., Williams, J.R., and Bartholomew, R.M. A new method for determining dose rate distribution from radioimmuno-therapy using radiochromic media. United States: N. p., 1994. Web. doi:10.1016/0360-3016(94)90078-7.
Mayer, R., Dillehay, L.E., Shao, Y., Song, S., Zhang, Y., Williams, J.R., & Bartholomew, R.M. A new method for determining dose rate distribution from radioimmuno-therapy using radiochromic media. United States. doi:10.1016/0360-3016(94)90078-7.
Mayer, R., Dillehay, L.E., Shao, Y., Song, S., Zhang, Y., Williams, J.R., and Bartholomew, R.M. Sat . "A new method for determining dose rate distribution from radioimmuno-therapy using radiochromic media". United States. doi:10.1016/0360-3016(94)90078-7.
@article{osti_6858696,
title = {A new method for determining dose rate distribution from radioimmuno-therapy using radiochromic media},
author = {Mayer, R. and Dillehay, L.E. and Shao, Y. and Song, S. and Zhang, Y. and Williams, J.R. and Bartholomew, R.M.},
abstractNote = {The purpose of this study is to describe and evaluate a new, simple, inexpensive method for directly measuring the radiation dose and its spatial distribution generated from explanted tissues of animals previously injected with radiolabeled immunoconjugates or other agents. This technique uses the newly developed radiochromic dye medium (Gafchromic[trademark]) which responds reproducibly for therapeutic dose exposures, has high spatial resolution, does not require film processing, and is relatively insensitive to ambient light. The authors have evaluated the dose distribution from LS174T tumors and selected normal tissues in nude mice previously injected with [sup 90]Y labeled anti-carcinoembryonic antigen antibodies. Individual tissues from sacrificed animals are halved and the flat section of the tissue is placed onto the dosimetry media and then frozen. The dosimetry medium is exposed to beta and Bremsstrahlung radiation originating from the frozen tissues. The relative darkening of the dosimetry medium depends on the dose deposited in the film. The dosimetry medium is scanned with a commercial flatbed scanner and the image intensity is digitally stored and quantitatively analyzed. Isodose curves are generated and compared to the actual tissue outline. The absorbed dose distribution due to [sup 90]Y exposure show only slight gradients in the interior of the tissue, with a markedly decreasing dose near the edges of the tissue. In addition, the isodose curves follow the tissue outline except in regions having radii of curvature smaller than the range of the beta-particle (R90 = 5 mm). These results suggest that the shape of the tumor, and its curvature, are important in determining the minimum dose delivered to the tumor by radiation from [sup 90]Y monoclonal antibodies, and hence in evaluating the tumor response to the radiation. 28 refs., 8 figs.},
doi = {10.1016/0360-3016(94)90078-7},
journal = {International Journal of Radiation Oncology, Biology and Physics; (United States)},
number = ,
volume = 28:2,
place = {United States},
year = {Sat Jan 15 00:00:00 EST 1994},
month = {Sat Jan 15 00:00:00 EST 1994}
}