Pulse radiolytic investigation of the hypoxanthine-xanthine-uric acid system: evidence for transient species

Journal Article · Thu Mar 01 00:00:00 EST 1984 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576135· OSTI ID:6855861

Santamaria, J; Pasquier, C; Ferradini, C; Pucheault, J

The oxidation in aqueous solutions of hypoxanthine into xanthine and xanthine into uric acid by OH radicals has been investigated using pulse radiolysis and fast kinetic absorption spectrophotometry. After hypoxanthine irradiations the spectrum of transient R/sub 1/ has been characterized. This radical is formed with a rate constant k/sub (Hyx+OH) = 6.5 x 10/sup 9/ M/sup -1/ sec/sup -1/ and disappears by disproportionation leading to xanthine and hypoxanthine with a rate constant 2K/sub (R/sub 1/+ r/sub 1// = 1.3 x 10/sup 8/ M/sup -1/ sec/sup -//sub 1/. After xanthine irradiations a radical intermediate R/sub 2/ is formed with a rate constant k/sub(X+ OH)/= 5.2 x 10/sup 8/ M/sup -1/ sec/sup -1/ and disappears through a second-order reaction 2K/sub (R/sub 2/+ R/sub 2/)/ = 2.0 x 10/sup 8/ M/sup -1/ sec/sup -1/. Finally, after aeration only uric acid and xanthine are measured.

• Research Organization: Universite Pierre et Marie Curie, Paris, France
• OSTI ID: 6855861
• Journal Information: Radiat. Res.; (United States), Vol. 97:3
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
HYDROXYL RADICALS
RADIOINDUCTION
HYPOXANTHINE
OXIDATION
RADIOLYSIS
URIC ACID
ABSORPTION SPECTRA
AQUEOUS SOLUTIONS
XANTHINES
AROMATICS
AZAARENES
CHEMICAL RADIATION EFFECTS
CHEMICAL REACTIONS
CHEMISTRY
DECOMPOSITION
DISPERSIONS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
MIXTURES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PURINES
RADIATION CHEMISTRY
RADIATION EFFECTS
RADICALS
SOLUTIONS
SPECTRA
400600* - Radiation Chemistry