The value of exercise radionuclide ventriculography in risk stratification in patients with known or suspected coronary artery disease

Conference · Wed May 01 00:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:6855144

Iskandrian, A S; Hakki, A H; Kane, S; Schenk, C

This study examined the value of rest and exercise (EX) radionuclide ventriculography (RNV) in risk stratification in 392 pts with suspected or known coronary artery disease who were being evaluated for anginal symptoms. There were 289 men and 203 women, aged 55 +- 12 years (mean +- SD). There were 20 cardiac events in the followup period of up to 4 years (19 +- 10 months): 14 pts died of cardiac causes and 6 had non-fatal acute myocardial infarctions. The pts with and without events did not differ in age, clinical presentation, risk factors, and rest and EX ECGs. However, pts with events had lower EX systolic blood pressure (p < 0.02); lower EX duration; (5.5 +- 2.5 vs 7.6 +- 3.7 minutes, p < 0.0l), lower resting left ventricular (LV) ejection fraction (EF) (p = 0.001), and lower EX EF (35 +- 17% vs 56 +- 15%, p = 0.0001). The change in EF from rest to EX was not significantly different (-0.1 +- 6.1 vs 3 +- 9.9). Univariate survival analysis (Cox model) showed several descriptors related to prognosis: EX EF, rest EF, wall motion and EX duration. Multivariate analysis, however, identified the EX EF as the only significant predictor (X/sup 2/ = 19.9). None of the other variables added independent information to that provided by the EX EF. Actuarial lie table analysis showed that the risk increased as the EX EF decreased, when pts were grouped into those with EXEF greater than or equal to 50%, 30-49%, and <30%., (p = 0.001, Mantel-Cox). Thus, the EX RNV is useful in risk stratification; the EX EF is the best descriptor that categorizes pts into different risk groups.

• Research Organization: Cardiovascular Institute, Hahnemann Univ., Philadelphia, PA
• OSTI ID: 6855144
• Report Number(s): CONF-850611-; TRN: 87-010739
• Journal Information: J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
CARDIOVASCULAR DISEASES
DISEASE INCIDENCE
RISK ASSESSMENT
THERAPY
HEART
CARDIOGRAPHY
DYNAMIC FUNCTION STUDIES
BIOLOGICAL RECOVERY
BIOLOGICAL STRESS
EVALUATION
EXERCISE
HEALING
HEALTH HAZARDS
PUBLIC HEALTH
BODY
CARDIOVASCULAR SYSTEM
DIAGNOSTIC TECHNIQUES
DISEASES
HAZARDS
ORGANS
RECOVERY
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550901 - Pathology- Tracer Techniques