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Title: Metallothionein synthesis and degradation: relationship to cadmium metabolism

Abstract

Metallothionein is an integral component of the mechanism that regulates the metabolism of cadmium and zinc. The metallothionein mRNA content of liver polysomes is increased shortly after an influx of small amounts of either metal into hepatocytes. After sufficient amounts of this poly (A+) RNA have been synthesized, there is a concomitant increase in metallothionein biosynthesis and metal binding. Unlike synthesis, the degradation of metallothionein is markedly influenced by the species of metal bound. Moreover, while the polypeptide chains of cadmium metallothionein are degraded, it appears that liberated cadmium ions are quickly incorporated into nascent chains of thionein. The latter explains why the cadmium content of liver and kidney increases with age and environmental exposure.

Authors:
Publication Date:
Research Org.:
State Univ. of New Jersey, New Brunswick
OSTI Identifier:
6852101
Alternate Identifier(s):
OSTI ID: 6852101
Resource Type:
Journal Article
Journal Name:
Environ. Health Perspect.; (United States)
Additional Journal Information:
Journal Volume: 28
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CADMIUM; METABOLISM; PROTEINS; BIODEGRADATION; BIOSYNTHESIS; MESSENGER-RNA; ANIMAL CELLS; KIDNEYS; LIVER; PHARMACOLOGY; RIBOSOMES; ZINC; BODY; CELL CONSTITUENTS; CHEMICAL REACTIONS; DECOMPOSITION; DIGESTIVE SYSTEM; ELEMENTS; GLANDS; METALS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; ORGANOIDS; ORGANS; RNA; SYNTHESIS 560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)

Citation Formats

Cousins, R.J. Metallothionein synthesis and degradation: relationship to cadmium metabolism. United States: N. p., 1979. Web. doi:10.1289/ehp.7928131.
Cousins, R.J. Metallothionein synthesis and degradation: relationship to cadmium metabolism. United States. doi:10.1289/ehp.7928131.
Cousins, R.J. Thu . "Metallothionein synthesis and degradation: relationship to cadmium metabolism". United States. doi:10.1289/ehp.7928131.
@article{osti_6852101,
title = {Metallothionein synthesis and degradation: relationship to cadmium metabolism},
author = {Cousins, R.J.},
abstractNote = {Metallothionein is an integral component of the mechanism that regulates the metabolism of cadmium and zinc. The metallothionein mRNA content of liver polysomes is increased shortly after an influx of small amounts of either metal into hepatocytes. After sufficient amounts of this poly (A+) RNA have been synthesized, there is a concomitant increase in metallothionein biosynthesis and metal binding. Unlike synthesis, the degradation of metallothionein is markedly influenced by the species of metal bound. Moreover, while the polypeptide chains of cadmium metallothionein are degraded, it appears that liberated cadmium ions are quickly incorporated into nascent chains of thionein. The latter explains why the cadmium content of liver and kidney increases with age and environmental exposure.},
doi = {10.1289/ehp.7928131},
journal = {Environ. Health Perspect.; (United States)},
number = ,
volume = 28,
place = {United States},
year = {1979},
month = {2}
}