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Title: Primary hemangiosarcoma of the spleen with angioscintigraphic demonstration of metastases

Abstract

A case of primary hemangiosarcoma of the spleen in a 48-year-old woman is presented. Twenty-eight months after splenectomy the patient developed a severe anemia of the microangiopathic type, thrombocytopenia, and a leukoerythroblastic peripheral blood picture. In contrast to x-ray and conventional /sup 99m/Tc-methylene-diphosphonate (MDP) bone scintigraphy, which showed only a few minor focal changes in the spine and ribs, angioscintigraphy with in vitro labeled /sup 99m/Tc-erythrocytes revealed extensive pathologic accumulations throughout the spine, femurs, and the liver, indicating the presence of extremely vascular metastases. Autopsy 15 months later confirmed the scintigraphic findings. Angiography with /sup 99m/Tc-labeled erythrocytes seems to be useful for monitoring metastases from hemangiosarcomas.

Authors:
; ; ; ;
Publication Date:
Research Org.:
Department of Hematology, Gentofte Hospital, Hellerup, Denmark
OSTI Identifier:
6850794
Alternate Identifier(s):
OSTI ID: 6850794
Resource Type:
Journal Article
Journal Name:
Cancer (Philadelphia); (United States)
Additional Journal Information:
Journal Volume: 53:8
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; SARCOMAS; METASTASES; SCINTISCANNING; DIAGNOSTIC USES; SKELETON; ERYTHROCYTES; HEMIC DISEASES; ISOMERIC NUCLEI; PATIENTS; SPLEEN; TECHNETIUM 99; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DISEASES; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MATERIALS; NEOPLASMS; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOISOTOPE SCANNING; RADIOISOTOPES; TECHNETIUM ISOTOPES; USES; YEARS LIVING RADIOISOTOPES 550601* -- Medicine-- Unsealed Radionuclides in Diagnostics

Citation Formats

Hermann, G.G., Fogh, J., Graem, N., Hansen, O.P., and Hippe, E. Primary hemangiosarcoma of the spleen with angioscintigraphic demonstration of metastases. United States: N. p., 1984. Web. doi:10.1002/1097-0142(19840415)53:8<1682::AID-CNCR2820530810>3.0.CO;2-C.
Hermann, G.G., Fogh, J., Graem, N., Hansen, O.P., & Hippe, E. Primary hemangiosarcoma of the spleen with angioscintigraphic demonstration of metastases. United States. doi:10.1002/1097-0142(19840415)53:8<1682::AID-CNCR2820530810>3.0.CO;2-C.
Hermann, G.G., Fogh, J., Graem, N., Hansen, O.P., and Hippe, E. Sun . "Primary hemangiosarcoma of the spleen with angioscintigraphic demonstration of metastases". United States. doi:10.1002/1097-0142(19840415)53:8<1682::AID-CNCR2820530810>3.0.CO;2-C.
@article{osti_6850794,
title = {Primary hemangiosarcoma of the spleen with angioscintigraphic demonstration of metastases},
author = {Hermann, G.G. and Fogh, J. and Graem, N. and Hansen, O.P. and Hippe, E.},
abstractNote = {A case of primary hemangiosarcoma of the spleen in a 48-year-old woman is presented. Twenty-eight months after splenectomy the patient developed a severe anemia of the microangiopathic type, thrombocytopenia, and a leukoerythroblastic peripheral blood picture. In contrast to x-ray and conventional /sup 99m/Tc-methylene-diphosphonate (MDP) bone scintigraphy, which showed only a few minor focal changes in the spine and ribs, angioscintigraphy with in vitro labeled /sup 99m/Tc-erythrocytes revealed extensive pathologic accumulations throughout the spine, femurs, and the liver, indicating the presence of extremely vascular metastases. Autopsy 15 months later confirmed the scintigraphic findings. Angiography with /sup 99m/Tc-labeled erythrocytes seems to be useful for monitoring metastases from hemangiosarcomas.},
doi = {10.1002/1097-0142(19840415)53:8<1682::AID-CNCR2820530810>3.0.CO;2-C},
journal = {Cancer (Philadelphia); (United States)},
number = ,
volume = 53:8,
place = {United States},
year = {1984},
month = {4}
}