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Title: Chromosomal location of the Syk and ZAP-70 tyrosine kinase genes in mice and humans

Abstract

Several protein tyrosine kinases (PTKs), which may be grouped into two structurally different families, have been implicated in antigen receptor proximal signaling. Blk, Fyn, Lck, Lyn, and Yes belong to the Src-family kinases, whereas the spleen tyrosine kinase (Syk) and the CD3-{zeta}-associated PTK (ZAP-70) define a new one, the Syk family. These kinases differ from the Src-family kinases in that they are non-myristylated cytoplasmic polypeptides composed of two N-terminal Src homology-2 (SH2) domains and a C-terminal catalytic domain. ZAP-70 appears to be expressed exclusively in T cells and NK cells, whereas Syk is preferentially expressed in B cells, T cells, and myeloid cells. 15 refs., 2 figs.

Authors:
;  [1];  [2]
  1. Centre d`Immunologie INSERM-CNRS de Marseille-Luminy (France)
  2. Hopital des Enfants, Marseille (France)
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
68498
Resource Type:
Journal Article
Journal Name:
Immunogenetics
Additional Journal Information:
Journal Volume: 40; Journal Issue: 4; Other Information: PBD: 1994
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; PHOSPHOTRANSFERASES; GENES; HUMAN CHROMOSOME 9; GENETIC MAPPING; HUMAN CHROMOSOME 2; METABOLIC ACTIVATION

Citation Formats

Ku, G, Malissen, B, and Mattei, M G. Chromosomal location of the Syk and ZAP-70 tyrosine kinase genes in mice and humans. United States: N. p., 1994. Web. doi:10.1007/BF00189976.
Ku, G, Malissen, B, & Mattei, M G. Chromosomal location of the Syk and ZAP-70 tyrosine kinase genes in mice and humans. United States. https://doi.org/10.1007/BF00189976
Ku, G, Malissen, B, and Mattei, M G. Sat . "Chromosomal location of the Syk and ZAP-70 tyrosine kinase genes in mice and humans". United States. https://doi.org/10.1007/BF00189976.
@article{osti_68498,
title = {Chromosomal location of the Syk and ZAP-70 tyrosine kinase genes in mice and humans},
author = {Ku, G and Malissen, B and Mattei, M G},
abstractNote = {Several protein tyrosine kinases (PTKs), which may be grouped into two structurally different families, have been implicated in antigen receptor proximal signaling. Blk, Fyn, Lck, Lyn, and Yes belong to the Src-family kinases, whereas the spleen tyrosine kinase (Syk) and the CD3-{zeta}-associated PTK (ZAP-70) define a new one, the Syk family. These kinases differ from the Src-family kinases in that they are non-myristylated cytoplasmic polypeptides composed of two N-terminal Src homology-2 (SH2) domains and a C-terminal catalytic domain. ZAP-70 appears to be expressed exclusively in T cells and NK cells, whereas Syk is preferentially expressed in B cells, T cells, and myeloid cells. 15 refs., 2 figs.},
doi = {10.1007/BF00189976},
url = {https://www.osti.gov/biblio/68498}, journal = {Immunogenetics},
number = 4,
volume = 40,
place = {United States},
year = {1994},
month = {12}
}