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Title: Basis for the ICRP`s age-specific biokinetic model for uranium

Abstract

In an effort motivated largely by the Chernobyl nuclear accident, the International Commission on Radiological Protection (ICRP) is developing age-specific biokinetic models and dose coefficients for environmentally important radionuclides. This paper describes the ICRP`s age-specific biokinetic model for uranium. The model is constructed within a physiologically based framework originally developed for application to the alkaline earth elements but sufficiently general to apply to the larger class of bone-volume-seeking elements. Transfer rates for a reference adult are based mainly on: (1) measurements of uranium in blood and excreta of several human subjects who were intravenously injected with uranium; (2) postmortem measurements of uranium in tissues of some of those subjects; (3) postmortem measurements of uranium in tissues of occupationally and non-occupationally exposed subjects; (4) data on baboons, dogs, and smaller laboratory animals exposed to uranium for experimental purposes; and (5) consideration of the physiological processes thought to control retention and translocation of uranium in the body. Transfer rates for the adult are extended to children by application of a set of generic assumptions applied by the ICRP to calcium-like elements. These assumptions were derived mainly from observations of the age-specific biokinetics of the alkaline earth elements and lead in humans andmore » laboratory animals but are consistent with available age-specific biokinetic data on uranium. 82 refs., 17 figs., 8 tabs.« less

Authors:
 [1]
  1. Oak Ridge National Lab., TN (United States)
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
68485
DOE Contract Number:  
AC05-84OR21400
Resource Type:
Journal Article
Journal Name:
Health Physics
Additional Journal Information:
Journal Volume: 67; Journal Issue: 6; Other Information: PBD: Dec 1994
Country of Publication:
United States
Language:
English
Subject:
56 BIOLOGY AND MEDICINE, APPLIED STUDIES; URANIUM; RADIONUCLIDE KINETICS; BIOLOGICAL MODELS; AGE DEPENDENCE; MATHEMATICAL MODELS

Citation Formats

Leggett, R W. Basis for the ICRP`s age-specific biokinetic model for uranium. United States: N. p., 1994. Web. doi:10.1097/00004032-199412000-00002.
Leggett, R W. Basis for the ICRP`s age-specific biokinetic model for uranium. United States. https://doi.org/10.1097/00004032-199412000-00002
Leggett, R W. 1994. "Basis for the ICRP`s age-specific biokinetic model for uranium". United States. https://doi.org/10.1097/00004032-199412000-00002.
@article{osti_68485,
title = {Basis for the ICRP`s age-specific biokinetic model for uranium},
author = {Leggett, R W},
abstractNote = {In an effort motivated largely by the Chernobyl nuclear accident, the International Commission on Radiological Protection (ICRP) is developing age-specific biokinetic models and dose coefficients for environmentally important radionuclides. This paper describes the ICRP`s age-specific biokinetic model for uranium. The model is constructed within a physiologically based framework originally developed for application to the alkaline earth elements but sufficiently general to apply to the larger class of bone-volume-seeking elements. Transfer rates for a reference adult are based mainly on: (1) measurements of uranium in blood and excreta of several human subjects who were intravenously injected with uranium; (2) postmortem measurements of uranium in tissues of some of those subjects; (3) postmortem measurements of uranium in tissues of occupationally and non-occupationally exposed subjects; (4) data on baboons, dogs, and smaller laboratory animals exposed to uranium for experimental purposes; and (5) consideration of the physiological processes thought to control retention and translocation of uranium in the body. Transfer rates for the adult are extended to children by application of a set of generic assumptions applied by the ICRP to calcium-like elements. These assumptions were derived mainly from observations of the age-specific biokinetics of the alkaline earth elements and lead in humans and laboratory animals but are consistent with available age-specific biokinetic data on uranium. 82 refs., 17 figs., 8 tabs.},
doi = {10.1097/00004032-199412000-00002},
url = {https://www.osti.gov/biblio/68485}, journal = {Health Physics},
number = 6,
volume = 67,
place = {United States},
year = {1994},
month = {12}
}