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Title: Correlation of cytotoxic activity in lungs to recovery of normal and gamma-irradiated cotton rats from respiratory syncytial virus infection

Abstract

Cotton rats (Sigmodon hispidus) that were exposed to 300, 600, or 900 rads of gamma irradiation and inoculated intranasally 2 days later with respiratory syncytial virus (RSV) exhibited prolonged virus shedding and delayed humoral and cytotoxic immune responses compared with comparably inoculated nonirradiated control rats. In nonirradiated animals and in animals exposed to 300 and 600 rads, levels of virus declined and then disappeared from the lungs during the period in which cytotoxic activity was maximal in the lungs of these animals. In contrast, in the group of cotton rats exposed to 900 rads of irradiation, local cytotoxic activity remained low throughout the 11-day observation period, and virus was not eliminated from the lungs. Although virus-neutralizing antibodies in serum and lavage fluids from these animals may have been involved, correlation of antibody concentrations with virus clearance from lungs was not as evident. These data suggest that cytotoxic effector cells have a positive role in eliminating RSV from the lungs of unprimed cotton rats.

Authors:
; ;
Publication Date:
OSTI Identifier:
6847451
Alternate Identifier(s):
OSTI ID: 6847451
Resource Type:
Journal Article
Resource Relation:
Journal Name: Am. Rev. Respir. Dis.; (United States); Journal Volume: 128:4
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; IMMUNE REACTIONS; BIOLOGICAL RADIATION EFFECTS; VIRUSES; INOCULATION; GAMMA SOURCES; INFECTIVITY; INFLUENZA; IRRADIATION; RADIATION DOSES; RATS; ANIMALS; BIOLOGICAL EFFECTS; DISEASES; DOSES; INFECTIOUS DISEASES; MAMMALS; MICROORGANISMS; PARASITES; RADIATION EFFECTS; RADIATION SOURCES; RODENTS; VERTEBRATES; VIRAL DISEASES 560152* -- Radiation Effects on Animals-- Animals

Citation Formats

Sun, C.S., Wyde, P.R., and Knight, V. Correlation of cytotoxic activity in lungs to recovery of normal and gamma-irradiated cotton rats from respiratory syncytial virus infection. United States: N. p., 1983. Web.
Sun, C.S., Wyde, P.R., & Knight, V. Correlation of cytotoxic activity in lungs to recovery of normal and gamma-irradiated cotton rats from respiratory syncytial virus infection. United States.
Sun, C.S., Wyde, P.R., and Knight, V. Sat . "Correlation of cytotoxic activity in lungs to recovery of normal and gamma-irradiated cotton rats from respiratory syncytial virus infection". United States.
@article{osti_6847451,
title = {Correlation of cytotoxic activity in lungs to recovery of normal and gamma-irradiated cotton rats from respiratory syncytial virus infection},
author = {Sun, C.S. and Wyde, P.R. and Knight, V.},
abstractNote = {Cotton rats (Sigmodon hispidus) that were exposed to 300, 600, or 900 rads of gamma irradiation and inoculated intranasally 2 days later with respiratory syncytial virus (RSV) exhibited prolonged virus shedding and delayed humoral and cytotoxic immune responses compared with comparably inoculated nonirradiated control rats. In nonirradiated animals and in animals exposed to 300 and 600 rads, levels of virus declined and then disappeared from the lungs during the period in which cytotoxic activity was maximal in the lungs of these animals. In contrast, in the group of cotton rats exposed to 900 rads of irradiation, local cytotoxic activity remained low throughout the 11-day observation period, and virus was not eliminated from the lungs. Although virus-neutralizing antibodies in serum and lavage fluids from these animals may have been involved, correlation of antibody concentrations with virus clearance from lungs was not as evident. These data suggest that cytotoxic effector cells have a positive role in eliminating RSV from the lungs of unprimed cotton rats.},
doi = {},
journal = {Am. Rev. Respir. Dis.; (United States)},
number = ,
volume = 128:4,
place = {United States},
year = {Sat Oct 01 00:00:00 EDT 1983},
month = {Sat Oct 01 00:00:00 EDT 1983}
}