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Title: The biodistribution and dosimetry of {sup 117m}Sn DTPA with special emphasis on active marrow absorbed doses

Abstract

{sup 117m}Sn(4+) DTPA is a new radiopharmaceutical for the palliation of pain associated with metastatic bone cancer. Recently, the Phase 2 clinical trials involving 47 patients were completed. These patients received administered activities in the range 6.7--10.6 MBq/kg of body mass. Frequent collections of urine were acquired over the first several hours postadministration and daily cumulative collections were obtained for the next 4--10 days. Anterior/posterior gamma camera images were obtained frequently over the initial 10 days. Radiation dose estimates were calculated for 8 of these patients. Each patient`s biodistribution data were mathematically simulated using a multicompartmental model. The model consisted of the following compartments: central, bone, kidney, other tissues, and cumulative urine. The measured cumulative urine data were used as references for the cumulative urine excretion compartment. The total-body compartment (sum of the bone surfaces, central, kidney, and other tissues compartments) was reference to all activity not excreted in the urine.

Authors:
 [1];  [2]
  1. Radiation Dosimetry Systems of Oak Ridge Inc., Knoxville, TN (United States)
  2. Brookhaven National Lab., Upton, NY (United States)
Publication Date:
Research Org.:
Oak Ridge Associated Universities, TN (United States)
Sponsoring Org.:
USDOE, Washington, DC (United States)
OSTI Identifier:
684484
Report Number(s):
ORISE-99-0164-Vol.1; CONF-960536-PROC.-Vol.1
ON: DE99002903; TRN: IM9943%%175
Resource Type:
Conference
Resource Relation:
Conference: 6. international radiopharmaceutical dosimetry symposium, Gatlinburg, TN (United States), 7-10 May 1996; Other Information: PBD: Jan 1999; Related Information: Is Part Of Sixth international radiopharmaceutical dosimetry symposium: Proceedings. Volume 1; S.-Stelson, A.T. [ed.] [comp.]; Stabin, M.G.; Sparks, R.B. [eds.]; Smith, F.B. [comp.]; PB: 386 p.
Country of Publication:
United States
Language:
English
Subject:
56 BIOLOGY AND MEDICINE, APPLIED STUDIES; 55 BIOLOGY AND MEDICINE, BASIC STUDIES; DOSIMETRY; RADIOTHERAPY; TIN 117; RADIATION DOSES; BONE MARROW; DTPA; SKELETON; METASTASES; MATHEMATICAL MODELS; TISSUE DISTRIBUTION

Citation Formats

Stubbs, J., and Atkins, H. The biodistribution and dosimetry of {sup 117m}Sn DTPA with special emphasis on active marrow absorbed doses. United States: N. p., 1999. Web.
Stubbs, J., & Atkins, H. The biodistribution and dosimetry of {sup 117m}Sn DTPA with special emphasis on active marrow absorbed doses. United States.
Stubbs, J., and Atkins, H. Fri . "The biodistribution and dosimetry of {sup 117m}Sn DTPA with special emphasis on active marrow absorbed doses". United States. https://www.osti.gov/servlets/purl/684484.
@article{osti_684484,
title = {The biodistribution and dosimetry of {sup 117m}Sn DTPA with special emphasis on active marrow absorbed doses},
author = {Stubbs, J. and Atkins, H.},
abstractNote = {{sup 117m}Sn(4+) DTPA is a new radiopharmaceutical for the palliation of pain associated with metastatic bone cancer. Recently, the Phase 2 clinical trials involving 47 patients were completed. These patients received administered activities in the range 6.7--10.6 MBq/kg of body mass. Frequent collections of urine were acquired over the first several hours postadministration and daily cumulative collections were obtained for the next 4--10 days. Anterior/posterior gamma camera images were obtained frequently over the initial 10 days. Radiation dose estimates were calculated for 8 of these patients. Each patient`s biodistribution data were mathematically simulated using a multicompartmental model. The model consisted of the following compartments: central, bone, kidney, other tissues, and cumulative urine. The measured cumulative urine data were used as references for the cumulative urine excretion compartment. The total-body compartment (sum of the bone surfaces, central, kidney, and other tissues compartments) was reference to all activity not excreted in the urine.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Fri Jan 01 00:00:00 EST 1999},
month = {Fri Jan 01 00:00:00 EST 1999}
}

Conference:
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