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Title: Uncertainty analysis for absorbed dose from a brain receptor imaging agent

Abstract

Absorbed dose estimates are known to contain uncertainties. A recent literature search indicates that prior to this study no rigorous investigation of uncertainty associated with absorbed dose has been undertaken. A method of uncertainty analysis for absorbed dose calculations has been developed and implemented for the brain receptor imaging agent {sup 123}I-IPT. The two major sources of uncertainty considered were the uncertainty associated with the determination of residence time and that associated with the determination of the S values. There are many sources of uncertainty in the determination of the S values, but only the inter-patient organ mass variation was considered in this work. The absorbed dose uncertainties were determined for lung, liver, heart and brain. Ninety-five percent confidence intervals of the organ absorbed dose distributions for each patient and for a seven-patient population group were determined by the ``Latin Hypercube Sampling`` method. For an individual patient, the upper bound of the 95% confidence interval of the absorbed dose was found to be about 2.5 times larger than the estimated mean absorbed dose. For the seven-patient population the upper bound of the 95% confidence interval of the absorbed dose distribution was around 45% more than the estimated population mean. Formore » example, the 95% confidence interval of the population liver dose distribution was found to be between 1.49E+0.7 Gy/MBq and 4.65E+07 Gy/MBq with a mean of 2.52E+07 Gy/MBq. This study concluded that patients in a population receiving {sup 123}I-IPT could receive absorbed doses as much as twice as large as the standard estimated absorbed dose due to these uncertainties.« less

Authors:
;  [1];  [2];  [3]
  1. Univ. of Tennessee, Knoxville, TN (United States). Nuclear Engineering Dept.
  2. Oak Ridge Inst. for Science and Education, TN (United States)
  3. Radiation Dosimetry Systems of Oak Ridge, Inc., Knoxville, TN (United States)
Publication Date:
Research Org.:
Oak Ridge Associated Universities, TN (United States)
Sponsoring Org.:
USDOE, Washington, DC (United States)
OSTI Identifier:
684480
Report Number(s):
ORISE-99-0164-Vol.2; CONF-960536-PROC.-Vol.2
ON: DE99002904; TRN: IM9943%%171
Resource Type:
Conference
Resource Relation:
Conference: 6. international radiopharmaceutical dosimetry symposium, Gatlinburg, TN (United States), 7-10 May 1996; Other Information: PBD: Jan 1999; Related Information: Is Part Of Sixth international radiopharmaceutical dosimetry symposium: Proceedings. Volume 2; S.-Stelson, A.T. [ed.] [comp.]; Stabin, M.G.; Sparks, R.B. [eds.]; Smith, F.B. [comp.]; PB: 401 p.
Country of Publication:
United States
Language:
English
Subject:
56 BIOLOGY AND MEDICINE, APPLIED STUDIES; DOSIMETRY; RADIOPHARMACEUTICALS; RADIATION DOSES; DATA COVARIANCES; BRAIN; RECEPTORS; IODINE 123; HEART; LIVER; LUNGS

Citation Formats

Aydogan, B, Miller, L F, Sparks, R B, and Stubbs, J B. Uncertainty analysis for absorbed dose from a brain receptor imaging agent. United States: N. p., 1999. Web.
Aydogan, B, Miller, L F, Sparks, R B, & Stubbs, J B. Uncertainty analysis for absorbed dose from a brain receptor imaging agent. United States.
Aydogan, B, Miller, L F, Sparks, R B, and Stubbs, J B. Fri . "Uncertainty analysis for absorbed dose from a brain receptor imaging agent". United States. https://www.osti.gov/servlets/purl/684480.
@article{osti_684480,
title = {Uncertainty analysis for absorbed dose from a brain receptor imaging agent},
author = {Aydogan, B and Miller, L F and Sparks, R B and Stubbs, J B},
abstractNote = {Absorbed dose estimates are known to contain uncertainties. A recent literature search indicates that prior to this study no rigorous investigation of uncertainty associated with absorbed dose has been undertaken. A method of uncertainty analysis for absorbed dose calculations has been developed and implemented for the brain receptor imaging agent {sup 123}I-IPT. The two major sources of uncertainty considered were the uncertainty associated with the determination of residence time and that associated with the determination of the S values. There are many sources of uncertainty in the determination of the S values, but only the inter-patient organ mass variation was considered in this work. The absorbed dose uncertainties were determined for lung, liver, heart and brain. Ninety-five percent confidence intervals of the organ absorbed dose distributions for each patient and for a seven-patient population group were determined by the ``Latin Hypercube Sampling`` method. For an individual patient, the upper bound of the 95% confidence interval of the absorbed dose was found to be about 2.5 times larger than the estimated mean absorbed dose. For the seven-patient population the upper bound of the 95% confidence interval of the absorbed dose distribution was around 45% more than the estimated population mean. For example, the 95% confidence interval of the population liver dose distribution was found to be between 1.49E+0.7 Gy/MBq and 4.65E+07 Gy/MBq with a mean of 2.52E+07 Gy/MBq. This study concluded that patients in a population receiving {sup 123}I-IPT could receive absorbed doses as much as twice as large as the standard estimated absorbed dose due to these uncertainties.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Fri Jan 01 00:00:00 EST 1999},
month = {Fri Jan 01 00:00:00 EST 1999}
}

Conference:
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