Ultraviolet-induced sister chromatid exchanges in V-79 cells with normal and BrdUrd-substituted DNA and the influence of intercalating substances and cysteine

Journal Article · Tue Jun 01 00:00:00 EDT 1982 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575731· OSTI ID:6842348

Speit, G; Mehnert, K; Wolf, M; Vogel, W

The influence of intercalating substances (proflavine, ethidium bromide) and of an SH compound (L-cysteine) on uv-induced sister chromatid exchanges (SCEs) was investigated in V-79 cells with normal and BrdUrd-substituted DNA. The results are discussed in relation to the primary damages leading to SCE induction produced by uv irradiation. The data indicate that neither the pyrimidine dimers nor DNA single-strand breaks are the primary cause of SCE induction, and that the damages leading to SCEs by uv irradiation differ from those which cause chromosome aberrations.

• Research Organization: Abteilung Klinische Genetik der Universitat, Ulm, Federal Republic of Germany
• OSTI ID: 6842348
• Journal Information: Radiat. Res.; (United States), Vol. 90:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
GENETIC RADIATION EFFECTS
CLATHRATES
BIOLOGICAL EFFECTS
CYSTEINE
SISTER CHROMATID EXCHANGES
RADIOINDUCTION
DIMERS
DNA
HAMSTERS
PROFLAVINE
PYRIMIDINES
STRAND BREAKS
ULTRAVIOLET RADIATION
ACRIDINES
AMINES
AMINO ACIDS
ANIMALS
AZINES
BIOLOGICAL RADIATION EFFECTS
CARBOXYLIC ACIDS
CHROMOSOMAL ABERRATIONS
ELECTROMAGNETIC RADIATION
FLAVINES
GENETIC EFFECTS
HETEROCYCLIC COMPOUNDS
MAMMALS
MUTAGENS
MUTATIONS
NUCLEIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PYRIDINES
RADIATION EFFECTS
RADIATIONS
RODENTS
THIOLS
VERTEBRATES
560121* - Radiation Effects on Cells- External Source- (-1987)