Single photon emission computed tomography in AIDS dementia complex

Journal Article · Mon Aug 01 00:00:00 EDT 1988 · J. Nucl. Med.; (United States)

OSTI ID:6837448

Pohl, P; Vogl, G; Fill, H; Roessler, H Z; Zangerle, R; Gerstenbrand, F

Single photon emission computed tomography (SPECT) studies were performed in AIDS dementia complex using IMP in 12 patients (and HM-PAO in four of these same patients). In all patients, SPECT revealed either multiple or focal uptake defects, the latter corresponding with focal signs or symptoms in all but one case. Computerized tomography showed a diffuse cerebral atrophy in eight of 12 patients, magnetic resonance imaging exhibited changes like atrophy and/or leukoencephalopathy in two of five cases. Our data indicate that both disturbance of cerebral amine metabolism and alteration of local perfusion share in the pathogenesis of AIDS dementia complex. SPECT is an important aid in the diagnosis of AIDS dementia complex and contributes to the understanding of the pathophysiological mechanisms of this disorder.

• Research Organization: Univ. of Innsbruck (Austria)
• OSTI ID: 6837448
• Journal Information: J. Nucl. Med.; (United States), Vol. 29:8
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
AIDS
DIAGNOSIS
BRAIN
ATROPHY
ELECTROENCEPHALOGRAPHY
NMR IMAGING
ORGANOMETALLIC COMPOUNDS
OXIMES
PATIENTS
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
AMINES
BODY
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
EMISSION COMPUTED TOMOGRAPHY
HEMIC DISEASES
HYDROXY COMPOUNDS
IMMUNE SYSTEM DISEASES
INFECTIOUS DISEASES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
TOMOGRAPHY
VIRAL DISEASES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550600 - Medicine