Linkage analysis of schizophrenia with five dopamine receptor genes in nine pedigrees
- Univ. of Utah, Salt Lake City (United States)
- Karolinska Inst., Stockholm (Sweden)
- Unite de Neurobiologie et de Pharmacologie de l'INSERM, Paris (France)
- Univ. of Colorado, Denver (United States)
Alterations in dopamine neurotransmission have been strongly implicated in the pathogenesis of schizophrenia for nearly 2 decades. Recently, the genes for five dopamine receptors have been cloned and characterized, and genetic and physical map information has become available. Using these five loci as candidate genes, the authors have tested for genetic linkage to schizophrenia in nine multigenerational families which include multiple affected individuals. In addition to testing conservative disease models, the have used a neurophysiological indicator variable, the P50 auditory evoked response. Deficits in gating of the P50 response have been shown to segregate with schizophrenia in this sample and may identify carriers of gene(s) predisposing for schizophrenia. Linkage results were consistently negative, indicating that a defect at any of the actual receptor sites is unlikely to be a major contributor to schizophrenia in the nine families studied. 47 refs., 1 fig., 4 tabs.
- OSTI ID:
- 6831059
- Journal Information:
- American Journal of Human Genetics; (United States), Vol. 52:2; ISSN 0002-9297
- Country of Publication:
- United States
- Language:
- English
Similar Records
Association study between the dopamine D4 receptor gene and schizophrenia
Further evidence of no linkage between schizophrenia and the dopamine D{sub 3} receptor gene locus
Related Subjects
DOPAMINE
MENTAL DISORDERS
RECEPTORS
GENE MUTATIONS
BIOLOGICAL INDICATORS
GENETIC MAPPING
HUMAN POPULATIONS
MAPS
AMINES
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
CARDIOTONICS
CARDIOVASCULAR AGENTS
DRUGS
HYDROXY COMPOUNDS
MAPPING
MEMBRANE PROTEINS
MUTATIONS
NEUROREGULATORS
ORGANIC COMPOUNDS
PHENOLS
POLYPHENOLS
POPULATIONS
PROTEINS
SYMPATHOMIMETICS
550400* - Genetics