Changes in activity of malate dehydrogenase and glucosephosphate isomerase in serum of rats exposed chronically to inorganic mercury and its aryl and alkyl compounds
In course of prolonged exposure (14 weeks) to various mercury compounds (MetHg - a fluid seed-dressing preparation 0,8, Phenyl and Ethyl chlorides and HgCl/sub 2/ in doses corresponding to 5% of DL/sub 50/, 3 times weekly), enhanced levels of activity of malate dehydrogenase (MDH) and glucosephosphate isomerase (PHI) in blood serum were observed. After 7 weeks of exposure about fourfold increase of MDH and 2-3-fold enhancement of PHI activities were found relative to controls. After 14 weeks of exposure in livers of rats, given MetHg and EtHg, organic mercury was found at concentrations of 28, 8 and 4 ..mu..g/g tissue, respectively. Inorganic mercury in liver was found in animals given all compounds and concentrations were in the range of 1,2 - 4,7 ..mu..g/g tissue.
- Research Organization:
- Inst. of Environmental Research and Bioanalysis, Lodz, Poland
- OSTI ID:
- 6829053
- Journal Information:
- Bull. Environ. Contam. Toxicol.; (United States), Vol. 17:4
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
ENZYME ACTIVITY
MERCURY
BIOLOGICAL EFFECTS
ALKYL RADICALS
ARYL RADICALS
BIOLOGICAL ACCUMULATION
BLOOD SERUM
CHLORIDES
CHRONIC INTAKE
DEHYDROGENASES
ENZYMES
ETHYL RADICALS
GLUCOSE
ISOMERASES
LIVER
METABOLISM
PHENYL RADICALS
PHOSPHATES
QUANTITY RATIO
RATS
ALDEHYDES
ANIMALS
BODY
CARBOHYDRATES
CHLORINE COMPOUNDS
DIGESTIVE SYSTEM
ELEMENTS
GLANDS
HALIDES
HALOGEN COMPOUNDS
HEXOSES
INTAKE
MAMMALS
METALS
MONOSACCHARIDES
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
OXYGEN COMPOUNDS
PHOSPHORUS COMPOUNDS
RADICALS
RODENTS
SACCHARIDES
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
550500 - Metabolism
550200 - Biochemistry