Gamma-emitting receptor-binding 3-quinuclidinyl gycolates; methods of preparation thereof and imaging and assay methods utilizing same

Patent · Tue Feb 14 00:00:00 EST 1984

OSTI ID:6816849

Eckelman, W C; Gibson, R E; Reba, R C; Rzeszotarski, W J

Compounds of the formula: ((1-R1-QUI NU CL I DIN-3-YL(+))-OOC-C (-R) (-OH)-), X-Benzene Z(-) wherein R is aryl, alkyl, cycloalkyl, phenyl, cyclopentyl, cyclohexyl, a ligand containing Tc-99m in chelated form or a ligand capable of chelating Tc-99m; R/sub 1/ is H or lower alkyl; X is in the ortho-, meta or para- position, and is selected from the group consisting of /sup 125/I, /sup 123/I, /sup 127/I, I, /sup 18/F, /sup 75/Br, /sup 77/Br, NH/sub 2/, and 1-(N=N-), R/sub 2/-Piperidine wherein R/sub 2/ is in the 2,3, or 4 position and is selected from the group consisting of H and lower alkyl, provided that when R is a ligand capable of chelating Tc-99m o containing Tc-99m in chelated form, X is not a radioisotope and may also be H or lower alkyl; Z/theta/ is an anion; or the free amine thereof; and denotes an asymmertric carbon atom.

• Assignee: Research Corporation
• Patent Number(s): US 4431627
• OSTI ID: 6816849
• Resource Relation: Patent File Date: Filed date 31 Dec 1981; Other Information: PAT-APPL-336340
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
PIPERIDINES
CHEMICAL PREPARATION
LABELLING
RADIOPHARMACEUTICALS
CHEMICAL COMPOSITION
BROMINE 75
BROMINE 77
CHELATING AGENTS
FLUORINE 18
GAMMA SOURCES
IODINE
IODINE 123
IODINE 125
IODINE 127
ISOMERIC NUCLEI
LIGANDS
RADIOASSAY
RADIOISOTOPE SCANNING
RECEPTORS
STRUCTURE-ACTIVITY RELATIONSHIPS
TECHNETIUM 99
AMINES
AZINES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BROMINE ISOTOPES
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
FLUORINE ISOTOPES
HALOGENS
HETEROCYCLIC COMPOUNDS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MINUTES LIVING RADIOISOTOPES
NONMETALS
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRIDINES
RADIATION SOURCES
RADIOISOTOPES
STABLE ISOTOPES
SYNTHESIS
TECHNETIUM ISOTOPES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
400700 - Radiochemistry & Nuclear Chemistry