Relationship of serum lipids to adrenal-gland uptake of 6. beta. -(/sup 131/I) iodomethyl-19-norcholesterol in Cushing's syndrome

Conference · Sat Nov 01 00:00:00 EST 1980 · J. Nucl. Med.; (United States)

OSTI ID:6795088

Valk, T W; Gross, M D; Freitas, J E; Swanson, D P; Schteingart, D E; Beierwaltes, W H

An alteration in serum cholesterol levels has been suggested as a possible modifier of adrenal uptake of the cholesterol analog, 6..beta..-(/sup 131/I)iodomethyl-19-norcholesterol (NP-59). To assess the effect of hypercholesterolemia upon NP-59 adrenal uptake, patients with Cushing's syndrome (eight with pituitary-dependent, four with ACTH-independent, and two with ectopic-ACTH syndrome) were selected for retrospective analysis based on the availability of serum cholesterol (n = 14) and triglyceride (n = 10) concentrations obtained at the time of adrenal scintigraphy. A negative correlation (r = -0.78, p < 0.01) was found between NP-59 uptake and serum cholesterol levels in patients with pituitary-dependent Cushing's disease. Compared with pituitary-dependent disease, the ectopic-ACTH syndrome and ACTH-independent states demonstrated equal or greater adrenal uptake of NP-59 at similar serum cholesterol concentrations. Serum triglyceride concentrations did not correlate with total adrenal uptake of NP-59 in any of the patient groups studied. Increased serum cholesterol concentrations are associated with diminished adrenal uptake of NP-59, and in some cases may limit the diagnoic efficacy of adrenal scintigraphy in Cushing's syndrome.

• Research Organization: Univ. of Michigan, Ann Arbor
• DOE Contract Number: EY-76-S-02-2031
• OSTI ID: 6795088
• Journal Information: J. Nucl. Med.; (United States), Vol. 21:11; Conference: 28. annual meeting of the Society of Nuclear Medicine, Las Vegas, NV, USA, 16 Jun 1981
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
ADRENAL GLANDS
SCINTISCANNING
IODINE 131
RADIONUCLIDE KINETICS
CHOLESTEROL
CUSHING SYNDROME
DIAGNOSIS
DIAGNOSTIC USES
IMMUNE SERUMS
LIPIDS
PATIENTS
QUANTITY RATIO
RESPONSE MODIFYING FACTORS
UPTAKE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
GLANDS
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
STEROIDS
STEROLS
USES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
551001 - Physiological Systems- Tracer Techniques