Phospholipid biosynthesis in Candida albicans: Regulation by the precursors inositol and choline

Journal Article · Wed Aug 01 00:00:00 EDT 1990 · Journal of Bacteriology; (USA)

OSTI ID:6794925

Klig, L S; Friedli, L; Schmid, E ^[1]

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1. GLAXO Institute for Molecular Biology S.A., Geneva (Switzerland)

Phospholipid metabolism in the pathogenic fungus Candida albicans was examined. The phospholipid biosynthetic pathways of C. albicans were elucidated and were shown to be similar to those of Saccharomyces cerevisiae. However, marked differences were seen between these two fungi in the regulation of the pathways in response to exogenously provided precursors inositol and choline. In S. cerevisiae, the biosynthesis of phosphatidylcholine via methylation of phosphatidylethanolamine appears to be regulated in response to inositol and choline; provision of choline alone does not repress the activity of this pathway. The same pathway in C. albicans responds to the exogenous provision of choline. Possible explanations for the observed differences in regulation are discussed.

• OSTI ID: 6794925
• Journal Information: Journal of Bacteriology; (USA), Vol. 172:8; ISSN 0021-9193
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
PHOSPHOLIPIDS
BIOSYNTHESIS
BIOLOGICAL PATHWAYS
CANDIDA
COMPARATIVE EVALUATIONS
HOMEOSTASIS
INOSITOL
ISOTOPE DILUTION
METHYLATION
PRECURSOR
SACCHAROMYCES CEREVISIAE
CARBOHYDRATES
CHEMICAL REACTIONS
ESTERS
EUMYCOTA
FUNGI
INOSITOLS
ISOTOPE APPLICATIONS
LIPIDS
MICROORGANISMS
MONOSACCHARIDES
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
PLANTS
SACCHARIDES
SACCHAROMYCES
SYNTHESIS
TRACER TECHNIQUES
YEASTS
550201* - Biochemistry- Tracer Techniques