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Title: Phospholipid biosynthesis in Candida albicans: Regulation by the precursors inositol and choline

Abstract

Phospholipid metabolism in the pathogenic fungus Candida albicans was examined. The phospholipid biosynthetic pathways of C. albicans were elucidated and were shown to be similar to those of Saccharomyces cerevisiae. However, marked differences were seen between these two fungi in the regulation of the pathways in response to exogenously provided precursors inositol and choline. In S. cerevisiae, the biosynthesis of phosphatidylcholine via methylation of phosphatidylethanolamine appears to be regulated in response to inositol and choline; provision of choline alone does not repress the activity of this pathway. The same pathway in C. albicans responds to the exogenous provision of choline. Possible explanations for the observed differences in regulation are discussed.

Authors:
; ;  [1]
  1. (GLAXO Institute for Molecular Biology S.A., Geneva (Switzerland))
Publication Date:
OSTI Identifier:
6794925
Alternate Identifier(s):
OSTI ID: 6794925
Resource Type:
Journal Article
Journal Name:
Journal of Bacteriology; (USA)
Additional Journal Information:
Journal Volume: 172:8; Journal ID: ISSN 0021-9193
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; PHOSPHOLIPIDS; BIOSYNTHESIS; BIOLOGICAL PATHWAYS; CANDIDA; COMPARATIVE EVALUATIONS; HOMEOSTASIS; INOSITOL; ISOTOPE DILUTION; METHYLATION; PRECURSOR; SACCHAROMYCES CEREVISIAE; CARBOHYDRATES; CHEMICAL REACTIONS; ESTERS; EUMYCOTA; FUNGI; INOSITOLS; ISOTOPE APPLICATIONS; LIPIDS; MICROORGANISMS; MONOSACCHARIDES; ORGANIC COMPOUNDS; ORGANIC PHOSPHORUS COMPOUNDS; PLANTS; SACCHARIDES; SACCHAROMYCES; SYNTHESIS; TRACER TECHNIQUES; YEASTS 550201* -- Biochemistry-- Tracer Techniques

Citation Formats

Klig, L.S., Friedli, L., and Schmid, E. Phospholipid biosynthesis in Candida albicans: Regulation by the precursors inositol and choline. United States: N. p., 1990. Web.
Klig, L.S., Friedli, L., & Schmid, E. Phospholipid biosynthesis in Candida albicans: Regulation by the precursors inositol and choline. United States.
Klig, L.S., Friedli, L., and Schmid, E. Wed . "Phospholipid biosynthesis in Candida albicans: Regulation by the precursors inositol and choline". United States.
@article{osti_6794925,
title = {Phospholipid biosynthesis in Candida albicans: Regulation by the precursors inositol and choline},
author = {Klig, L.S. and Friedli, L. and Schmid, E.},
abstractNote = {Phospholipid metabolism in the pathogenic fungus Candida albicans was examined. The phospholipid biosynthetic pathways of C. albicans were elucidated and were shown to be similar to those of Saccharomyces cerevisiae. However, marked differences were seen between these two fungi in the regulation of the pathways in response to exogenously provided precursors inositol and choline. In S. cerevisiae, the biosynthesis of phosphatidylcholine via methylation of phosphatidylethanolamine appears to be regulated in response to inositol and choline; provision of choline alone does not repress the activity of this pathway. The same pathway in C. albicans responds to the exogenous provision of choline. Possible explanations for the observed differences in regulation are discussed.},
doi = {},
journal = {Journal of Bacteriology; (USA)},
issn = {0021-9193},
number = ,
volume = 172:8,
place = {United States},
year = {1990},
month = {8}
}