Convenient preparation of /sup 11/C-methyltriphenylphosphonium iodide (MTP) for PET imaging of regional myocardial blood flow
The purpose of this study was to synthesize and evaluate /sup 11/C-MTP for use as a potential regional myocardial perfusion agent in positron emission tomography. The synthesis of /sup 11/C-MTP was accomplished by reacting triphenylphosphine with /sup 11/C- methyliodide. Triphenylphosphine was dissolved in benzene and cooled to O/sup 0/C in a septum sealed reaction vessel. /sup 11/C-methyliodide was synthesized from /sup 11/C-carbon dioxide, and bubbled through the reaction vessel in a stream of carrier nitrogen gas. When trapping of the /sup 11/C- methyliodide was complete, the vessel was placed in a block heater at 140/sup 0/C for 5 minutes. The reaction mixture was cooled and evaporated to dryness under reduced pressure. The residue was dissolved in absolute ethanol and then re-evaporated to dryness. The final product was dissolved in saline and passed through a 0.2 micron filter which removed excess unreacted tiphenylphosphine. The specific activity of the /sup 11/C-MTP was determined to be at least 10 mCi/..mu..mole using UV spectroscopy. PET imaging was performed on anesthetized dogs (normal and surgically infarcted hearts) and monkeys which were injected i.v. with a solution of 20 mCi of /sup 11/C-MTP. Scans of the heart were acquired using the authors' neuro ECAT. The myocardium was clearly visualized in both the dog and monkey. In dogs with myocardial infarctions, images showed an absence of radiotracer in regions corresponding to the infarcted zone. These studies indicate that /sup 11/C-MTP can be conveniently prepared to provide tomographic imaging of the heart using PET. Moreover, the uptake of /sup 11/C-MTP in the heart may be useful in determining regional myocardial blood flow.
- Research Organization:
- Hahnemann Univ., Philadelphia, PA
- OSTI ID:
- 6793456
- Report Number(s):
- CONF-840619-; TRN: 87-010807
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 25:5; Conference: 31. annual meeting of the Society of Nuclear Medicine, Los Angeles, CA, USA, 5 Jun 1984
- Country of Publication:
- United States
- Language:
- English
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37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
CARBON 11
RADIOCHEMISTRY
MYOCARDIAL INFARCTION
DIAGNOSIS
MYOCARDIUM
BLOOD FLOW
ECAT SCANNING
POSITRON COMPUTED TOMOGRAPHY
PHOSPHINES
DIAGNOSTIC USES
RADIOPHARMACEUTICALS
CHEMICAL PREPARATION
BENZENE
COOLING
DISSOLUTION
DOGS
IMAGES
INTRAVENOUS INJECTION
METHYL IODIDE
MONKEYS
TRACER TECHNIQUES
ULTRAVIOLET SPECTRA
UPTAKE
ANIMALS
AROMATICS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBON ISOTOPES
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHEMISTRY
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
HALOGENATED ALIPHATIC HYDROCARBONS
HEART
HYDROCARBONS
INJECTION
INTAKE
IODINATED ALIPHATIC HYDROCARBONS
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
MINUTES LIVING RADIOISOTOPES
MUSCLES
NUCLEI
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANS
PHOSPHORUS COMPOUNDS
PHOTON EMISSION SCANNING
PRIMATES
RADIOISOTOPES
SPECTRA
SYNTHESIS
TOMOGRAPHY
USES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550602 - Medicine- External Radiation in Diagnostics- (1980-)
400202 - Isotope Effects
Isotope Exchange
& Isotope Separation